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Observation |

Paradoxical Reaction During a Course of Terbinafine Treatment of Trichophyton interdigitale Infection in a Child

Anita Hryncewicz-Gwóźdź, MD, PhD1; Marta Wojciechowska-Zdrojowy, MD, PhD1; Joanna Maj, MD, PhD1; Wojciech Baran, MD, PhD1; Tomasz Jagielski, PhD2
[+] Author Affiliations
1Department of Dermatology, Allergology, and Venereology, Wrocław Medical University, Wrocław, Poland
2Department of Applied Microbiology, Institute of Microbiology, Faculty of Biology, University of Warsaw, Warsaw, Poland
JAMA Dermatol. 2016;152(3):342-343. doi:10.1001/jamadermatol.2015.4293.
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Unique reaction during Trichophyton interdigitale infection terbinafine treatment.

We describe for the first time, to our knowledge, a paradoxical reaction to terbinafine treatment in the context of dermatophyte infection due to Trichophyton interdigitale.

Article InformationCorresponding Author: Tomasz Jagielski, PhD, Department of Applied Microbiology, Institute of Microbiology, Faculty of Biology, University of Warsaw, I. Miecznikowa 1, 02-096 Warsaw, Poland (t.jagielski@biol.uw.edu.pl).

Published Online: December 2, 2015. doi:10.1001/jamadermatol.2015.4293.

Conflict of Interest Disclosures: None reported.

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Clinical Details of the Jarisch-Herxheimer–Like Reaction Observed in Our Study

Inflammatory lesions on the abdomen and forearm of a patient on admission (A) and 12 hours after initiation of terbinafine treatment (B).

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