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Comment & Response |

Association Between Leukemia and Topical Use of Pimecrolimus—Reply

David J. Margolis, MD, PhD1,2; Katrina Abuabara, MD, MA2; Ole J. Hoffstad, MS1; Joy Wan, MD2; Denise Raimondo, MSEd3; Warren B. Bilker, PhD1
[+] Author Affiliations
1Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia
2Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia
3Valeant Pharmaceuticals International, Bridgewater, New Jersey
JAMA Dermatol. 2015;151(12):1391-1392. doi:10.1001/jamadermatol.2015.3492.
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In Reply We thank Drs Yew and Tey for their interest in our study.1 We are, however, concerned about their interpretation of our study results. Secondary analyses, as well as interpretations of analyses that were not part of the original study design, can result in spurious conclusions. Our study was not designed to evaluate only individuals of aged 1 to 4 years and was not designed to specifically study acute lymphoblastic leukemia (ALL). The investigation was designed to study all cancer and lymphoma in children (aged 2 to 18 years) as a group who were or will be followed for up to 10 years.

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December 1, 2015
Yik Weng Yew, MBBS, MPH; Hong Liang Tey, MBBS, FRCP(Edin)
1National Skin Centre, Singapore
JAMA Dermatol. 2015;151(12):1390-1391. doi:10.1001/jamadermatol.2015.3445.
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