0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
In This Issue of JAMA Dermatology |

Highlights FREE

JAMA Dermatol. 2015;151(12):1275. doi:10.1001/jamadermatol.2014.2951.
Text Size: A A A
Published online

RESEARCH

Histologic regression in primary melanoma is fairly commonly observed. Yet the prognostic significance of this regression remains unclear, and no consensus exists regarding the need for sentinel lymph node biopsy (SLNB) when it is present. In this systematic review of the literature, Ribero et al demonstrate that the risk of micrometastases in SLNB was significantly lower in patients with histologic regression in the primary tumor than in those without. Regression may be used in these cases to select the patients for whom SLNB is most appropriate.

Skin cancers are strongly associated with preventable risk behaviors related to UV exposure, including outdoor sun exposure and indoor tanning. Data suggest that gay and bisexual men may be more likely to engage in indoor tanning, but skin cancer prevalence among gay and bisexual men compared with heterosexual men has never been studied. In this cross-sectional study, Mansh et al demonstrate that gay and bisexual men tan more frequently and report higher skin cancer rates than heterosexual men. Prevention efforts targeted at sexual minority men might reduce risk factors for, and consequences of, skin cancer.

Dermatologists, pulmonologists, and rheumatologists study and treat patients with sarcoidosis with cutaneous manifestations. The validity of cutaneous sarcoidosis outcome instruments for use across medical specialties remains unknown. In this cross-sectional study, Yeung et al evaluate several reference instruments, demonstrating that the Cutaneous Sarcoidosis Activity and Morphology Instrument (CSAMI) and Sarcoidosis Activity and Severity Index (SASI) were reliable and valid in assessing cutaneous sarcoidosis among these specialists. The CSAMI Activity score also correlated with quality-of-life measures and suggested construct validity.

Despite its relevance to delivery of health care, the economic impact of store-and-forward teledermatology has only modest representation in the medical literature. In this randomized study in Veterans Affairs (VA) medical facilities, Datta et al compared the cost and utility of referrals to dermatology services using store-and-forward teledermatology or a conventional text-based referral process. Teledermatology was comparable in cost from a VA perspective and less costly from the societal perspective.

Dermatofibromasarcoma protuberans (DFSP) is a rare, slow-growing skin cancer that develops in the deep dermis to subcutaneous adipose tissues. The pathogenesis of DFSP involves a chromosome 17 and 22 translocation, inducing formation of a fusion gene between COL1A1 and PDGFB genes in most patients. In this study, Nakamura et al demonstrate that PDGFB expression was detected in 93% of patients with DFSP. In 1 tumor, the COL1A1-PDGFB fusion gene was not detected even though PDGFB protein was expressed. A novel COL1A2-PDGFB fusion gene was found in this tumor. These findings suggest that PDGFB protein expression may be a useful diagnostic tool when used in conjunction with previously described immunohistochemical markers.

Figures

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

1,069 Views
0 Citations
×

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs