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Comment & Response |

Concerns About Presence of a Wild-Type BAP1 Allele in Absence of Nuclear Protein Expression

Andrea Napolitano, MD1; Michele Carbone, MD, PhD1
[+] Author Affiliations
1University of Hawai’i Cancer Center, Honolulu, Hawaii
JAMA Dermatol. 2015;151(11):1265-1266. doi:10.1001/jamadermatol.2015.3136.
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To the Editor As fellow researchers investigating the recently described BAP1 tumor predisposition syndrome (OMIM 614327), we read with great interest the recent report “Multiple Cutaneous Melanomas and Clinically Atypical Moles in a Patient With a Novel Germline BAP1 Mutation” by Gerami et al.1 The evidence of dysplastic nevus syndrome in the presence of germline BAP1 mutations could prove indeed very useful in the clinical setting.

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November 1, 2015
Pedram Gerami, MD; Oriol Yélamos, MD; Christina Y. Lee, BA; Roxana Obregon, BA; Pedram Yazdan, MD; Lauren M. Sholl, MS; Gerta E. Guitart; Ching-Ni Njauw, MS; Hensin Tsao, MD, PhD
1Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois2Robert H. Lurie Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois
1Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois
3Wellman Center for Photomedicine and Department of Dermatology, Massachusetts General Hospital, Harvard University, Boston4Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston
JAMA Dermatol. 2015;151(11):1235-1239. doi:10.1001/jamadermatol.2015.1701.
November 1, 2015
Pedram Gerami, MD; Hensin Tsao, MD, PhD
1Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois2Robert H. Lurie Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois
3Wellman Center for Photomedicine and Department of Dermatology, Massachusetts General Hospital, Harvard University, Boston, Massachussets4Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
JAMA Dermatol. 2015;151(11):1266. doi:10.1001/jamadermatol.2015.3127.
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