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Research Letter |

Epidemiology and Treatment of Eosinophilic Fasciitis An Analysis of 63 Patients From 3 Tertiary Care Centers

Natalie A. Wright, MD1; Daniel R. Mazori, BA2; Mital Patel, MD1; Joseph F. Merola, MD, MMSC1; Alisa N. Femia, MD2; Ruth Ann Vleugels, MD, MPH1
[+] Author Affiliations
1Department of Dermatology, Brigham and Women’s Hospital, Boston, Massachusetts
2The Ronald O. Perelman Department of Dermatology, New York University Langone Medical Center, New York
JAMA Dermatol. 2016;152(1):97-99. doi:10.1001/jamadermatol.2015.3648.
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This study reports that misdiagnoses, unnecessary procedures, and undertreatment were common among patients with eosinophilic fasciitis, while combination therapy with corticosteroids and methotrexate resulted in higher rates of complete response.

Eosinophilic fasciitis (EF) is a rare fibrosing disorder of the fascia characterized by erythema, edema, and induration of the bilateral extremities. Joint contractures and related functional limitation commonly occur owing to fascial involvement overlying the joints. Hematologic abnormalities, including peripheral eosinophilia and monoclonal gammopathy, may occur. Systemic corticosteroids are considered first-line therapy; however, prolonged treatment is frequently required in patients with EF, and a standardized therapeutic protocol is lacking.1,2 Given the dearth of systematic data guiding treatment, we evaluated the presentation and clinical response of EF in 63 patients at 3 tertiary care centers.

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