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BRAF Inhibition in a Lung Transplant Recipient With Metastatic Melanoma

Kambiz Afshar, MD1; Sascha David, MD2; Thomas Fuehner, MD3; Jens Gottlieb, MD3; Ralf Gutzmer, MD4
[+] Author Affiliations
1Institute for General Practice, Hannover Medical School, Hannover, Germany
2Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany
3Department of Pulmonary Medicine, Hannover Medical School, Hannover, Germany
4Department of Dermatology and Allergy, Skin Cancer Center Hannover, Hannover Medical School, Hannover, Germany
JAMA Dermatol. 2016;152(2):228-230. doi:10.1001/jamadermatol.2015.2910.
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This case report illustrates BRAF inhibition in a lung transplant recipient with metastatic melanoma.

New treatment options like the BRAF inhibitors have been established for immunocompetent patients with metastatic melanoma, but experience in organ transplant recipients is lacking.

Article InformationCorresponding Author: Kambiz Afshar, MD, Institute for General Practice, Hannover Medical School, Carl-Neuberg-Str 1, 30625 Hannover, Germany (Afshar.Kambiz@mh-hannover.de).

Published Online: October 21, 2015. doi:10.1001/jamadermatol.2015.2910.

Conflict of Interest Disclosures: Dr David has received funds and grants for research and fees for consultancy and speaking from Silence Therapeutics AG unrelated to the topic of this report. Dr Gutzmer has received honoraria and project, travel, and meeting support from Roche Pharmaceuticals and GlaxoSmithKline.

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Axial Computed Tomographic Scans of the Chest Before and After 2 Months of Vemurafenib Treatment

A substantial reduction of the pulmonary metastases is apparent 2 months after initiation of vemurafenib therapy.

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Figure 2.
Cerebral Magnetic Resonance Images Before and After 2 Months of Vemurafenib Treatment

Substantial disease progression is evident in cerebral metastases 2 months after initiation of vemurafenib therapy.

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