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Bullous Pemphigoid Associated With Linagliptin Treatment

Roger Haber, MD1,2; Alice Mouna Fayad, MD1,2; Farid Stephan, MD1,2; Grace Obeid, MD3; Roland Tomb, MD, PhD1,2
[+] Author Affiliations
1Department of Dermatology, Hotel Dieu de France University Hospital, Beirut, Lebanon
2Faculty of Medicine, Saint Joseph University, Beirut Lebanon
3Department of Dermatology, Sacre Coeur Hospital, Beirut, Lebanon
JAMA Dermatol. 2016;152(2):224-226. doi:10.1001/jamadermatol.2015.2939.
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This report of cases describes 2 patients with bullous pemphigoid associated with linagliptin treatment for diabetes.

Drug-induced bullous pemphigoid (BP) has been recently reported in association with sitagliptin and vildagliptin, 2 dipeptidyl peptidase-4 (DPP-4) inhibitors used in the treatment of type 2 diabetes mellitus (T2DM). Herein, we report the development of BP in 2 patients with T2DM treated with linagliptin, another DPP-4 inhibitor.

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Figure 1.
Clinical Image of Patient 1 With Linagliptin-Induced Bullous Pemphigoid

This picture was taken 4 months after the start of treatment with linagliptin and shows tense bullae on an erythematous base disseminated on the arm.

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Figure 2.
Histopathologic Image of a Subepidermal Blister Biopsy Specimen From Case 1 of Linagliptin-Induced Bullous Pemphigoid

Four months after the start of treatment with linagliptin, the epithelial layer is seen detaching from the dermis, and an inflammatory infiltrate is present (hematoxylin-eosin, original magnification ×10).

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