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Subacute Cutaneous Lupus Erythematosus Induced by Mitotane

Ander Mayor-Ibarguren, MD1; María Concepción Roldán-Puchalt, MD2; Cristina Gómez-Fernández, MD1; Fátima Albízuri-Prado, MD1; Cristina Álvarez-Escola, MD2
[+] Author Affiliations
1Department of Dermatology, La Paz Hospital, Madrid, Spain
2Department of Endocrinology, La Paz Hospital, Madrid, Spain
JAMA Dermatol. 2016;152(1):109-111. doi:10.1001/jamadermatol.2015.2702.
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This case report describes a patient with subacute cutaneous lupus erythematosus induced by mitotane.

Drug-induced subacute cutaneous lupus erythematosus (DISCLE) presents similar clinical and serological characteristics to idiopathic SCLE. The following report describes a case of DISCLE induced by mitotane.

Article InformationCorresponding Author: Ander Mayor-Ibarguren, MD, Department of Dermatology, La Paz Hospital, Paseo de la Castellana 261, Z.C 28046 Madrid, Spain (andermayor@gmail.com).

Published Online: October 7, 2015. doi:10.1001/jamadermatol.2015.2702.

Conflict of Interest Disclosures: None reported.

Additional Contributions: We are indebted to the patient for allowing us to use this material for scientific purposes. We would also like to thank John Turcany, language services consultant, for language corrections. Mr Turcany received no compensation for his contributions beyond that received in the normal course of his employment.

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Figure 1.
Subacute Cutaneous Lupus Erythematous Eruption

A papulosquamous eruption is seen distributed along the back.

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Figure 2.
Biopsy Specimens From a Lesion on the Back

A, Perivascular infiltration of the dermis is evident, with vacuolar degeneration of the dermoepidermal junction along with some apoptotic keratinocytes and perivascular lymphocyte infiltration (original magnification ×40). B, Colloidal iron stain reveals a noteworthy mucin deposit in the upper and lower dermis (original magnification ×20).

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