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Research Letter |

Influence of Fcγ Receptor Polymorphisms on Response to Anti–Tumor Necrosis Factor Treatment in Psoriasis

Ana Batalla, MD1; Eliecer Coto, PhD2; Pablo Coto-Segura, MD, PhD1
[+] Author Affiliations
1Department of Dermatology II, Hospital Universitario Central Asturias, Oviedo, Spain
2Department of Molecular Genetics, Hospital Universitario Central Asturias, Oviedo, Spain
JAMA Dermatol. 2015;151(12):1376-1378. doi:10.1001/jamadermatol.2015.2818.
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This observational study sought to determine whether FCGR2A and FCGR3A single-nucleotide polymorphisms were associated with the response to biological treatment of psoriasis in a Spanish cohort.

Biological agents have greatly improved the prognosis of psoriasis. However, these treatments are expensive, and 20% to 50% of patients do not achieve an adequate clinical response.1 Therefore, identifying the biomarkers that predict the response could lead to individualized, more effective treatments.1

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