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Research Letter |

Effect of Calcium Channel Blockade on Vismodegib-Induced Muscle Cramps

Mina S. Ally, MD1; Jean Y. Tang, MD, PhD1; Joselyn Lindgren, MS2; Maria Acosta-Raphael, BA2; Melika Rezaee, BA2; Anita M. Chanana, BS2; Ervin H. Epstein Jr, MD2
[+] Author Affiliations
1Department of Dermatology, Stanford University, Stanford, California
2Children’s Hospital Oakland Research Institute, Oakland, California
JAMA Dermatol. 2015;151(10):1132-1134. doi:10.1001/jamadermatol.2015.1937.
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This study of vismodegib-treated patients reports the therapeutic benefit of amlodipine for vismodegib-related muscle cramps.

Aberrant hedgehog (HH) pathway signaling is the pivotal molecular abnormality in all basal cell carcinomas whether occurring sporadically or as part of the rare autosomal dominant disease basal cell nevus (Gorlin) syndrome (OMIM 109400).1 Vismodegib (Erivedge, GDC-0449), an oral HH pathway inhibitor, is approved by the Food and Drug Administration for the treatment of locally advanced and metastatic basal cell carcinomas.2

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Figure.
Mean Change in Cramp Frequency, Cramp Severity, Cramp Duration, and Night Awakenings Over Time From Baseline With Amlodipine Treatment in 8 Patients

Mean values at each time point refer to the 2-week period preceding the respective telephone-administered questionnaire. Arrowheads indicate the point at which amlodipine treatment was initiated. Patients who experienced a reduction in cramp frequency noted efficacy within 2 weeks of starting amlodipine treatment, and the benefits were maintained throughout the 8-week trial.

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