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A Case of Dominant Dystrophic Epidermolysis Bullosa Responding Well to an Old Medication

Jordan Leung, BSc1; Paul Kuzel, MD1; Anil Kurian, MD1; Alain Brassard, MD, FRCPC1
[+] Author Affiliations
1Division of Dermatology and Cutaneous Sciences, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
JAMA Dermatol. 2015;151(11):1264-1265. doi:10.1001/jamadermatol.2015.1791.
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This case report describes effective treatment of dominant dystrophic epidermolysis bullosa with minocycline.

Epidermolysis bullosa (EB) is an inherited disease characterized by fragile skin and bullae or erosion formation, either spontaneously or on minor skin trauma. Molecular defects within the epidermis or the skin’s basement membrane indicate which subtype of EB a patient has. Collagen VII is affected in dystrophic EB.1,2 The mainstay of disease management involves wound care, symptom palliation, and prevention or treatment of complications. However, there is still no consistently effective treatment that minimizes or prevents formation of bullae on minor skin trauma.

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