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Case Report/Case Series |

Tofacitinib Citrate for the Treatment of Vitiligo A Pathogenesis-Directed Therapy

Brittany G. Craiglow, MD1; Brett A. King, MD, PhD1
[+] Author Affiliations
1Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut
JAMA Dermatol. 2015;151(10):1110-1112. doi:10.1001/jamadermatol.2015.1520.
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ABSTRACT

Importance  Vitiligo is a common condition that is often emotionally devastating for patients. At present, no reliably effective treatments are available.

Observations  Recent advances in the understanding of the pathogenesis of vitiligo suggest that Janus kinase inhibitors may be a therapeutic option. We report a case of generalized vitiligo for which treatment with tofacitinib citrate, an oral Janus kinase 1/3 inhibitor, resulted in significant repigmentation.

Conclusions and Relevance  The results suggest that tofacitinib and other Janus kinase inhibitors may be effective in the treatment of vitiligo. Additional studies will be needed to confirm their efficacy and to explore their safety.

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Figure 1.
Forehead of the Patient Before and After Treatment With Tofacitinib Citrate

A, At baseline, numerous white macules and patches are evident. B, After 5 months of treatment, repigmentation is nearly complete.

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Figure 2.
Hands of the Patient Before and After Treatment With Tofacitinib Citrate

A, At baseline, numerous white macules and patches are evident. B, After 5 months of treatment, repigmentation is nearly complete.

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