Accepted for Publication: December 11, 2014.
Published Online: March 25, 2015. doi:10.1001/jamadermatol.2014.5479.
Study concept and design: Menting, Coussens, de Jong, Spuls, Lambert.
Acquisition, analysis, or interpretation of data: All authors
Drafting of the manuscript: Menting, Coussens.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Menting, Coussens, Pouw, Temmerman.
Obtained funding: Spuls, Lambert.
Administrative, technical, or material support: Menting, Coussens, van den Reek, Temmerman, Boonen, Spuls.
Study supervision: de Jong, Spuls, Lambert.
Conflict of Interest Disclosures: Dr Menting had carried out clinical trials for AbbVie, Pfizer, Amgen, and Novartis. Dr van den Reek has received speaking fees from AbbVie and had carried out clinical trials for AbbVie and Janssen. Dr Boonen had paid consultancies from Pfizer, AbbVie, Janssen, MSD and Leo Pharma and had carried out clinical trials for AbbVie. Dr de Jong has received speaking fees from AbbVie, MSD, Janssen, and Pfizer; has received grants from AbbVie, Pfizer, and Janssen; and had carried out clinical trials for AbbVie, MSD, Janssen, and Pfizer. Dr Spuls has received grants from Schering-Plough and LEO Pharma; had paid consultancies from Leo Pharma, AbbVie, and Novartis; and had carried out clinical trials for Leo Pharma, Janssen-Cilag, Almirall, Schering-Plough, Merck Serono, Amgen, Pfizer, Biogen Idec, Centocor, Roche, Eli Lilly, AbbVie, Celgene, Novartis, and Astellas. Dr Lambert has received grants from Janssen, AbbVie, and Pfizer; had paid consultancies from Pfizer, Novartis, AbbVie, Janssen Cilag, and Leo Pharma; and had carried out clinical trials for Janssen-Cilag, Merck Serono, Amgen, Pfizer, AbbVie, Celgene, Regeneron and Novartis. No other disclosures are reported
Additional Contributions: G. A. Appel, H. M. Bonnerjee–van der Stok, and L.L.A. Lecluse, MD, PhD (Academic Medical Center, Amsterdam, the Netherlands), and M. E. Otero, P. van Lumig, MD, PhD, and J. Zweegers, MD (Radboudumc, Nijmegen, the Netherlands), recruited patients for this study. They did not receive any financial compensation.