Atopic dermatitis (AD) is a chronic pruritic skin disorder with an increasing prevalence rate that mirrors the increasing prevalence rate of obesity during a similar timeframe. Atopic dermatitis is associated with multiple potential risk factors for obesity and high blood pressure (BP), including chronic inflammation, sleep disturbance, and mental health comorbidity. In this observational case-control study, Silverberg et al uncover several new associations related to metabolic issues in children with AD, particularly related to central obesity and elevated BP. The mechanism of association between obesity and AD remains unknown. These data suggest that pediatric patients may benefit from routine adiposity and BP screening.