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Correspondence |

Bacillary Angiomatosis After Skin Autografting in a Patient Without Human Immunodeficiency Virus Who Was Treated With Interferon Alfa

Su Fei, MD; Li Feng, MD; Jin Hongzhong, MD
Arch Dermatol. 2010;146(8):918-935. doi:10.1001/archdermatol.2010.190.
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Kempf  VALebiedziejewski  MAlitalo  K  et al.  Activation of hypoxia-inducible factor-1 in bacillary angiomatosis: evidence for a role of hypoxia-inducible factor-1 in bacterial infections. Circulation 2005;111 (8) 1054- 1062
PubMed Link to Article[[XSLOpenURL/10.1161/01.CIR.0000155608.07691.B7]]
von Marschall  ZScholz  ACramer  T  et al.  Effects of interferon alpha on vascular endothelial growth factor gene transcription and tumor angiogenesis. J Natl Cancer Inst 2003;95 (6) 437- 448
PubMed Link to Article[[XSLOpenURL/10.1093/jnci/95.6.437]]
Wu  WZSun  HCShen  YF  et al.  Interferon alpha 2a down-regulates VEGF expression through PI3 kinase and MAP kinase signaling pathways. J Cancer Res Clin Oncol 2005;131 (3) 169- 178
PubMed Link to Article[[XSLOpenURL/10.1007/s00432-004-0615-2]]
Ezekowitz  RAMulliken  JBFolkman  J Interferon alfa-2a therapy for life-threatening hemangiomas of infancy. N Engl J Med 1992;326 (22) 1456- 1463
PubMed Link to Article[[XSLOpenURL/10.1056/NEJM199205283262203]]
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Figure 1.

Before (A and B) and after (C and D) clinical images of our patient. A and B, Before treatment, 3 huge angiomatous lesions were evident on the dorsal aspect of the left hand and left side of the abdomen. C and D, After treatment, scars and hyperpigmentation were seen at the sites of the angiomatous lesions. The scale in panel D indicates centimeters.

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Figure 2.

Biopsy specimens. A, Numerous dilated small blood vessels with swollen endothelial cells in the entire dermis (hematoxylin-eosin, original magnification ×40). B, Solitary or clustered bacilli in and around the vessel walls (Warthin-Starry stain, original magnification ×1000).

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