Author Contributions:All authors had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Rommel, Ciurea, Fife, Kuzel, Wayne, Rademaker, West, and Alam. Acquisition of data: St Pierre, Rommel, and Fife. Analysis and interpretation of data: St Pierre, Yoo, Martini, Kuzel, and Alam. Drafting of the manuscript: St Pierre, Kuzel, and Rademaker. Critical revision of the manuscript for important intellectual content: Rommel, Ciurea, Fife, Yoo, Martini, Wayne, West, and Alam. Statistical analysis: Rademaker. Obtained funding: Alam. Administrative, technical, and material support: St Pierre, Rommel, Ciurea, Fife, Yoo, Martini, and West. Study supervision: Fife and Alam.