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Correspondence |

Rare Cutaneous Manifestation of Prostate Cancer

Jonathan R. Van Meter, MD; Cindy England Owen, MD; Soon Bahrami, MD; Jeffrey P. Callen, MD
Arch Dermatol. 2010;146(2):206-208. doi:10.1001/archdermatol.2009.381.
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Prostate cancer is the most frequent internal malignant neoplasm in men, but it represents only a minority of cutaneous metastases. In a meta-analysis of cutaneous metastasis, Krathen et al1 report that the overall incidence of cutaneous metastases from visceral cancers appears to be around 5%. The highest incidence of cutaneous metastasis was seen in breast cancer, occurring with an incidence of 24%. In the same meta-analysis, prostate cancer was the least likely visceral malignant neoplasm to metastasize to the skin (0.7% incidence).1 Herein, we describe a patient with multiple cutaneous nodules as the presenting sign of recurrent prostate cancer.

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Figure 1

The patient presented with the simultaneous appearance of multiple telangiectatic and firm nodules. A, Firm, telangiectatic nodule on the forehead. B, Pedunculated, telangiectatic nodule of the anterior neck.

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Figure 2

Histopathologic images. A, Low-power view demonstrates a nodular infiltrate (hematoxylin-eosin, original magnification ×40). B, Higher-power magnification demonstrates regions of glandular differentiation in addition to nuclear pleomorphism and atypia (hematoxylin-eosin, original magnification ×400). C, Clear-cell changes were noted in some areas (hematoxylin-eosin, original magnification ×400). D, Focally positive findings for prostate-specific antigen (PSA) (PSA, original magnification ×200).

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