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JAMA Dermatology Clinical Evidence Synopsis |

Topical Anti-inflammatory Agents for Seborrheic Dermatitis of the Face or Scalp Summary of a Cochrane Review

Helena Kastarinen, MD, PhD1; Enembe O. Okokon, MD, MSc2; Jos H. Verbeek, MD, PhD3
[+] Author Affiliations
1Social Insurance Institute of Finland, Regional Office for Eastern Finland, Kuopio, Finland
2Department of Community Medicine, University of Calabar Teaching Hospital, Calabar, Nigeria
3Cochrane Occupational Safety and Health Review Group, Finnish Institute of Occupational Health, Kuopio, Finland
JAMA Dermatol. 2015;151(2):221-222. doi:10.1001/jamadermatol.2014.3186.
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Clinical Question  Are there differences in effectiveness between topical anti-inflammatory treatments (steroids, calcineurin inhibitors, or lithium salts) and placebo or azoles in the treatment of seborrheic dermatitis of the face and scalp in adults?

Bottom Line  The topical anti-inflammatory treatments were more effective in achieving total clearance of symptoms than placebo by 1.4-fold to 8.5-fold, but there are no considerable differences in the anti-inflammatory topical treatments or in comparison with azoles for short-term treatment. There is no evidence of treatment effects in long-term, continuous, or intermittent use of these compounds despite the chronic nature of the disease.

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