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Comment & Response |

Indications and Limitations of Afamelanotide for Treating Vitiligo—Reply

Henry W. Lim, MD1; Pearl E. Grimes, MD2; Mark Lebwohl, MD3
[+] Author Affiliations
1Multicultural Dermatology Center, Department of Dermatology, Henry Ford Hospital, Detroit, Michigan
2Vitiligo and Pigmentation Institute of Southern California, Los Angeles
3Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York
JAMA Dermatol. 2015;151(3):350. doi:10.1001/jamadermatol.2014.4951.
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In reply On behalf of all coauthors, we would like to thank Dr Passeron for his interest in our publication.1 We agree with the statement that because the melanogenic effect of afamelanotide requires the presence of melanocortin-1 receptor (MC1R), stimulation of melanoblast differentiation by phototherapy is required. This very point was discussed in our previous proof-of-concept article on narrowband UV-B–afamelanotide combination therapy.2 In fact, this was the rationale for the study design, in which patients were treated with narrowband UV-B for 4 weeks prior to the administration of afamelanotide.

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January 1, 2015
Henry W. Lim, MD; Pearl E. Grimes, MD; Oma Agbai, MD; Iltefat Hamzavi, MD; Marsha Henderson, MD; Madelaine Haddican, MD; Rita V. Linkner, MD; Mark Lebwohl, MD
1Multicultural Dermatology Center, Department of Dermatology, Henry Ford Hospital, Detroit, Michigan
2Vitiligo and Pigmentation Institute of Southern California, Los Angeles
1Multicultural Dermatology Center, Department of Dermatology, Henry Ford Hospital, Detroit, Michigan3Department of Dermatology, University of California, Davis, Sacramento
4Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York
JAMA Dermatol. 2015;151(1):42-50. doi:10.1001/jamadermatol.2014.1875.
March 1, 2015
Thierry Passeron, MD, PhD
1Department of Dermatology, University Hospital of Nice, Nice, France
JAMA Dermatol. 2015;151(3):349-350. doi:10.1001/jamadermatol.2014.4848.
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