Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
In This Issue of JAMA Dermatology |

Highlights FREE

JAMA Dermatol. 2015;151(1):5. doi:10.1001/jamadermatol.2014.2896.
Text Size: A A A
Published online


Allogeneic hematopoietic stem cell transplantation offers potential cure for certain hematologic diseases, but its use is limited by graft-vs-host disease (GvHD). Although cutaneous manifestations of chronic GvHD are highly variable and may resemble well-characterized autoimmune diseases, vitiligo and alopecia areata (AA) have not been well characterized in this setting. In this cross-sectional, retrospective study, Zuo et al demonstrate that, although vitiligo and AA were uncommon phenomena in this population, female donor and female donor to male recipient sex mismatch were significantly associated with the development of these conditions.

Eczema is a chronic inflammatory disorder that causes significant morbidity related to itch, sleep impairment, and a wide range of comorbidities. In this prospective questionnaire-based study, Garg and Silverberg demonstrate an increased risk of fracture and bone or joint injury among adults with a history of eczema. Adults with both eczema and fatigue or sleep symptoms demonstrated higher rates. Lowered bone mineral density due to chronic corticosteroid use or chronic inflammation may also play a role, and developing safer, more effective clinical interventions for itch and sleep problems may be effective preventive measures for injury reduction in eczema.

Narrowband UV-B phototherapy is used extensively to treat vitiligo. Subcutaneous injection of afamelanotide, an analogue of α-melanocyte–stimulating hormone, is known to increase skin pigmentation and has been proven useful in the treatment of erythropoietic protoporphyria and solar urticaria. In this multicenter randomized study, Lim et al demonstrate that afamelanotide administration to patients receiving narrowband UV-B phototherapy for vitiligo significantly enhanced the rate and total surface area of repigmentation.

Cutaneous melanoma is 1 of the 5 most common cancers in the United States and is the most common fatal malignant neoplasm in young adults. Several cohort studies have suggested a higher incidence of melanoma in pilots and flight crew, thought to be at greater risk due to altitude-related exposure to UV and cosmic radiation. In this meta-analysis, Sanlorenzo et al demonstrate that pilots and cabin crew had approximately twice the incidence of melanoma compared with the general population. The mechanisms underlying this risk and methods for optimal occupational protection merit further study.

Indoor tanning is widespread in the United States despite evidence establishing it as a risk factor for skin cancer. Tanning salons are ubiquitous in US cities and are particularly concentrated near colleges. In this observational study, Pagoto et al demonstrate that approximately half of US colleges have indoor tanning facilities on campus or in off-campus housing and that campus cash cards could be used to purchase tanning for 14.4% of colleges. In step with tobacco-free policies, tanning-free policies on college campuses may have the potential to reduce skin cancer risk in young adults.





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Related Content

Customize your page view by dragging & repositioning the boxes below.