0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Comment & Response |

Trichodysplasia Spinulosa in Gorlin Syndrome Treated With Vismodegib—Reply

Justin D. Richey, MD1; Terrence Katona, DO1,2; Jeffrey B. Travers, MD, PhD3
[+] Author Affiliations
1Department of Pathology, Indiana University School of Medicine, Indianapolis
2Richard L. Roudebush Veteran’s Affairs Medical Center, Indianapolis, Indiana
3Department of Dermatology, Indiana University School of Medicine, Indianapolis
JAMA Dermatol. 2015;151(4):459. doi:10.1001/jamadermatol.2014.4388.
Text Size: A A A
Published online

Extract

In Reply We appreciate the letter in response to our case report. We acknowledge the limitations in making a diagnosis of trichodysplasia spinulosa (TS) using only clinical and histologic findings.

Electron microscopy (EM) was attempted in our case, but the diagnostic area was exhausted. We want to emphasize that owing to our patient’s syndrome, he had undergone a multitude of procedures and imaging studies. Therefore, from a compassionate standpoint, and at the patient’s request, additional biopsies of the spiny facial lesions were not performed. Although virus was not confirmed, we believe that the clinical (central face, folliculocentric) and histologic (trichohyalin debris in inner root sheath cells) features of this case are very similar to those of virus-proven cases of TS, both in publication and presented at a recent American Society of Dermatopathology meeting.1,2 Other cases of targeted therapy–induced follicular hyperkeratosis do not demonstrate the same trichohyalin debris or inclusions.3

Topics

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

January 1, 2015
Sander van Boheemen, MSc; Terry Jones, PhD; Barbara Muhlemann, BSc; Mariet C. Feltkamp, PhD; Ron A. M. Fouchier, PhD; Enes Hajdarbegovic, MD
1Department of Viroscience, Erasmus Medical Centre, Rotterdam, the Netherlands
2Center for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge, England
3Department of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands
4Department of Dermatology and Venereology, Erasmus Medical Centre, Rotterdam, the Netherlands
JAMA Dermatol. 2015;151(1):82-84. doi:10.1001/jamadermatol.2014.1616.
April 1, 2015
Gregory A. Hosler, MD, PhD; Lisa Weibel, MD; Richard C. Wang, MD, PhD
1Department of Dermatology, University of Texas Southwestern Medical Center, Dallas
2Department of Dermatology, University Hospital Zurich, Zurich, Switzerland
JAMA Dermatol. 2015;151(4):457-458. doi:10.1001/jamadermatol.2014.4379.
April 1, 2015
Ingrid Lopez-Lerma, MD, PhD; Jordi Mollet, MD; Vicente Garcia-Patos, MD, PhD
1Department of Dermatology, Hospital Universitari Vall d’Hebron, Barcelona, Spain
JAMA Dermatol. 2015;151(4):458-459. doi:10.1001/jamadermatol.2014.4382.
April 1, 2015
Sander van Boheemen, PhD; Ron A. M. Fouchier, PhD; Enes Hajdarbegovic, MD
1Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands
2Department of Dermatology and Venereology, Erasmus Medical Center, Rotterdam, the Netherlands
JAMA Dermatol. 2015;151(4):458. doi:10.1001/jamadermatol.2014.4385.
CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

393 Views
0 Citations
×

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Jobs
brightcove.createExperiences();