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Comment & Response |

The Cause of Follicular Spicules in Multiple Myeloma—Reply

Sander van Boheemen, PhD1; Ron A. M. Fouchier, PhD1; Enes Hajdarbegovic, MD2
[+] Author Affiliations
1Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands
2Department of Dermatology and Venereology, Erasmus Medical Center, Rotterdam, the Netherlands
JAMA Dermatol. 2015;151(4):458. doi:10.1001/jamadermatol.2014.4385.
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In Reply We are grateful to our colleagues for their contribution in consolidating the available knowledge on follicular spicules in multiple myeloma (FSMM). Gathering evidence on rare disorders is hampered by nonuniform terminology and variations in methodology in addition to the limited number of cases. The great similarity between the clinical pictures of FSMM and trichodysplasia spinulosa (TS) has led to clinicians mistaking the 2 diagnoses.1 Our article2 describes the first exhaustive, robust, and modern method of virologic analysis, which enabled us to exclude the presence, and therefore direct involvement, of TS polyomavirus (TSPyV) in FSMM. It is surprising that this had not been attempted before, given the similarities between TS and FSMM.

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January 1, 2015
Sander van Boheemen, MSc; Terry Jones, PhD; Barbara Muhlemann, BSc; Mariet C. Feltkamp, PhD; Ron A. M. Fouchier, PhD; Enes Hajdarbegovic, MD
1Department of Viroscience, Erasmus Medical Centre, Rotterdam, the Netherlands
2Center for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge, England
3Department of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands
4Department of Dermatology and Venereology, Erasmus Medical Centre, Rotterdam, the Netherlands
JAMA Dermatol. 2015;151(1):82-84. doi:10.1001/jamadermatol.2014.1616.
April 1, 2015
Gregory A. Hosler, MD, PhD; Lisa Weibel, MD; Richard C. Wang, MD, PhD
1Department of Dermatology, University of Texas Southwestern Medical Center, Dallas
2Department of Dermatology, University Hospital Zurich, Zurich, Switzerland
JAMA Dermatol. 2015;151(4):457-458. doi:10.1001/jamadermatol.2014.4379.
April 1, 2015
Ingrid Lopez-Lerma, MD, PhD; Jordi Mollet, MD; Vicente Garcia-Patos, MD, PhD
1Department of Dermatology, Hospital Universitari Vall d’Hebron, Barcelona, Spain
JAMA Dermatol. 2015;151(4):458-459. doi:10.1001/jamadermatol.2014.4382.
April 1, 2015
Justin D. Richey, MD; Terrence Katona, DO; Jeffrey B. Travers, MD, PhD
1Department of Pathology, Indiana University School of Medicine, Indianapolis
1Department of Pathology, Indiana University School of Medicine, Indianapolis2Richard L. Roudebush Veteran’s Affairs Medical Center, Indianapolis, Indiana
3Department of Dermatology, Indiana University School of Medicine, Indianapolis
JAMA Dermatol. 2015;151(4):459. doi:10.1001/jamadermatol.2014.4388.
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