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Original Investigation |

Purse-String Suture vs Second Intention Healing Results of a Randomized, Blind Clinical Trial FREE

Jayne Joo, MD1; Trenton Custis, MD1; April W. Armstrong, MD, MPH2; Thomas H. King, MD1; Kenny Omlin, MD1,3; Stefani T. Kappel, MD4; Daniel B. Eisen, MD1
[+] Author Affiliations
1Department of Dermatology, University of California Davis Medical Center, Sacramento
2Department of Dermatology, University of Colorado Denver School of Medicine, Aurora
3Department of Dermatology, The Permanente Medical Group, Vacaville, California
4Laser & Skin Surgery Center of Northern California, Sacramento
JAMA Dermatol. 2015;151(3):265-270. doi:10.1001/jamadermatol.2014.2313.
Text Size: A A A
Published online

Importance  Purse-string suture is a closure method that purportedly reduces the scar area compared with second intention healing. Randomized clinical trials comparing these 2 methods appear to be limited or absent.

Objective  To determine if purse-string suture improves cosmetic outcome, healing time, and scar to defect area compared with second intention healing for circular defects on the trunk and extremities.

Design, Setting, and Participants  Prospective, 2-arm, randomized, evaluator-blinded clinical trial in a single-center outpatient academic dermatology center. Patients were eligible if they were older than 18 years, able to give informed consent, and had circular or oval postoperative defects larger than 8 mm on the trunk or extremities.

Interventions  For the purse-string treatment arm, wounds were sewn in circumferential fashion using polydiaxanone suture. Patients in the other treatment arm were allowed to heal by second intent.

Main Outcomes and Measures  The primary outcome measures were the mean total Patient and Observer Scar Assessment Scale (POSAS) scores ascertained from the patient and 2 blinded observers. Secondary outcomes included the ratio of scar to initial defect size, healing time, pain scores, and complication rates.

Results  Fifty-two patients were screened, and a total of 44 patients with 50 surgical sites were enrolled. Forty-two patients with 48 surgical sites completed the study. The mean total observer POSAS score was 18.38 for the purse-string group vs 19.91 for the secondary intention group, a nonsignificant difference (P = .41). Similarly, there were no significant differences for any of the following secondary outcome measures: mean total patient POSAS score (P = .96), mean scar-to-defect area (P = .61), and mean pain level at week 1 (P = .19). Statistical trends toward significance were seen in the mean healing time in favor of purse-string suture (P = .10) and scar relief, which favored second intention healing (P = .07).

Conclusions and Relevance  The purse-string suture results in similar cosmetic outcomes, scar sizes, and pain levels compared with second intention healing for circular or oval wounds on the trunk and extremities. A larger study might better define the potential differences in our secondary outcome measures of healing time and scar relief.

Trial Registration  clinicaltrials.gov Identifier: NCT02062866

Figures in this Article

The purse-string suture for cutaneous surgical defects was first described in 1985.1 It is a wound closure technique that is often used in cutaneous surgery for complete or partial closure of circular postoperative defects.2,3 Proponents of the purse-string suture have claimed this technique reduces scar area, expedites healing time, enhances hemostasis, and improves aesthetic outcome, with long-term cosmetic and functional results being comparable with other methods of wound repair.39 Data regarding outcomes of purse-string suture have mostly pertained to colostomies1012 or mastopexies.1315

In the dermatologic surgery literature, studies are primarily composed of medical record review or case illustrations demonstrating examples of purse-string suture of circular defects, along with variations thereof, on various anatomic sites and with relatively good cosmetic outcome.5,1624 Randomized clinical trials comparing purse-string suture with other treatment methods appear limited in the cutaneous surgery literature.

Second intention healing is a commonly used alternative to purse-string suture, with acceptable outcomes and low complication rates.25 We sought to determine if purse-string suture improves the cosmetic outcome, healing time, and ratio of scar to defect area compared with second intention healing for wounds on the torso and extremities.

Study Design, Registration, Training, and Ethical Consent

In this prospective, 2-arm, randomized, evaluator-blinded, registered clinical trial, patients were continually enrolled between July 1, 2013, and October 18, 2013. Ethical approval was obtained through the University of California, Davis, Institutional Review Board before study commencement, and all patients provided verbal and written consent to enroll. An author with significant purse-string suture experience (K.O.) trained all the study surgeons during a pig’s foot practice laboratory at study inception.

Patient Eligibility

Patients were eligible for enrollment if they were older than 18 years, able to give informed consent, and had postoperative defects larger than 8 mm (in greatest diameter or length of circular or oval geometric shape) on the trunk or extremities (including the shin, hands, and feet).

Patients were excluded from the study if they were mentally handicapped, unable to understand written and oral English, incarcerated, unwilling or unable to return for follow-up, or pregnant; if their wounds were less than 8 mm in greatest diameter or length or located on the head, neck, or digits; or if primary linear closure was preferred or recommended.

Power Analysis and Randomization

The Patient and Observer Scar Assessment Scale (POSAS), a validated surgical outcome measure, was used as the primary outcome measure for the power analysis.26 A priori power analysis suggested that we would need to enroll 50 patients to obtain 80% power and an α of .05, assuming a standard deviation of 7, a mean difference of 6 points on the 60-point POSAS, and a 10% patient dropout rate. Randomization was predetermined using a freely available web service based on atmospheric noise.27 A nurse not involved with study recruitment generated the list. Study assignments obtained from the randomization list were concealed in sealed, sequentially numbered opaque envelopes and stored in the office of the same nurse who generated the list. After study enrollment, treatment assignment was determined by opening the envelope in the presence of the patient and surgeon.

Interventions and Allocation Concealment

The intervention arm was recorded in a web-based data capture form (REDCap)28 after opening the preassigned envelope. The database administrator locked the form containing the intervention type after data recording to ensure allocation concealment.

For wounds allocated to the purse-string group, undermining and suture preference (3-0, 4-0, or 5-0 polydiaxanone suture on a P3 needle) was based on wound size and left to the discretion of the surgeon performing the procedure. The wound was sewn in a circumferential fashion, with close approximation of the intradermal entry and exit points, until the entire wound was encompassed with suture. Tension was applied to the suture material and the wound decreased to the minimum wound area possible without tissue strangulation. The suture was then tied and allowed to remain until it dissolved on its own accord. Following purse-string suture, patients were told to avoid strenuous physical activity for 1 week, change their dressings daily, and apply petroleum jelly using a cotton-tipped applicator to the wound daily until it healed.

For the second intention healing group, petroleum jelly was applied to the wound immediately after the procedure and a sterile pressure dressing was applied to the area. There were no activity restrictions; otherwise, the wound care instructions were the same as those for the purse-string group.

Assessments

The primary outcome measures were the observer and patient POSAS scores. Secondary outcomes included the ratio of scar size to initial defect size, healing time, pain scores, and complication rates.

We obtained basic demographic data following intervention assignment at patient enrollment. This included the patient’s date of birth, sex, and race. Before intervention, the defect size was measured in terms of length and width using a sterile ruler. If the patient was randomized to the purse-string arm, the residual unclosed defect size after closure was also recorded after the procedure.

The patient was contacted weekly after their surgical procedure via e-mail or telephone until either their wound was fully healed or 12 weeks had passed since enrollment. Patients were queried as to whether their wound was healed and what their pain level was on a 1-to-10 scale, 1 being no pain and 10 being the worst pain imaginable.

The scars for both study groups were measured at a single follow-up visit after 3 months. Two masked investigators performed most follow-up scar assessments in person (T.C. and D.B.E.), and when either investigator had been involved in the actual procedure, a different investigator was asked to perform the scar assessment. The scar area for each wound was calculated from length by width measurements using a ruler. The scar to defect ratio for both treatment arms was calculated by dividing the scar area by the unsutured postoperative defect area. All assessment data were recorded in web-based data capture forms.28

Statistical Analysis

A t test was performed on the data obtained for the primary and secondary outcome measures for each treatment group to determine statistical significance. Complications such as infection, bleeding, spitting sutures, dehiscence, telangiectasia, erythema, contour irregularity, and hypertrophic scar were evaluated using the Fischer exact test to determine if there were any differences in rates between the purse-string and second intention groups.

Fifty-two patients were screened to enroll a total of 44 patients with 50 surgical sites. Eight declined to participate: 2 were unwilling to follow up and 6 preferred an alternative treatment method. Forty-two patients with 48 surgical sites completed the study, yielding a 96% follow-up rate. Two patients, 1 from each treatment group, were lost to follow-up; both were owing to medical problems unrelated to the study.

Most of the patients recruited for this study were white men with a mean age of 69 years, most of whom had treatment sites located on the upper and lower extremities (Table 1). The demographic characteristics and surgical wounds were similar in both treatment groups.

The observer mean total POSAS score, one of our primary outcome measures, was 18.38 for the purse-string group and 19.91 for the second intention group (lower scores indicate better outcomes). This difference was not statistically significant (P = .41). The observer mean overall opinion scores were 4.40 for the purse-string group and 4.15 for the second intention group, a nonsignificant difference (P = .68). Subcategory outcomes from the observer POSAS score, such as scar vascularity, pigmentation, thickness, relief, pliability, and surface area are listed in Table 2. None of these outcomes showed statistical significance, including the measure for relief of second intention healing (P = .07).

Table Graphic Jump LocationTable 2.  Results of POSAS Measurements

The mean total patient POSAS scores were 17.76 for the purse-string group and 17.61 for the second intention group, a nonsignificant difference (P = .96). Similarly, there was no significant difference (P = .92) in the mean overall patient impression score between the purse-string group (4.04) and the second intention group (3.96). Other outcomes, such as pain, itching, color, stiffness, thickness, and contour irregularity are listed in Table 2. None of these outcomes showed statistical significance.

Other secondary outcome measures included scar to defect ratio, healing time, mean pain score at 1 week, duration of pain level greater than 1, and complication rates (infection, bleeding, spitting sutures, dehiscence, erythema, contour irregularity, and hypertrophic scar) (Figure and Table 3 and Table 4). The mean scar to defect ratio for the purse-string group was 0.39 vs 0.43 for the second intention group (P = .61) (lower numbers indicate better healing). The mean healing time was 5.62 weeks for the purse-string group and 7.43 weeks for the second intention group (P = .10). The mean pain level at week 1 was 1.69 for the purse-string group and 2.22 for the second intention group (P = .19). The mean duration of a pain level greater than 1 was 1.12 weeks for the purse-string group and 1.96 weeks for the second intention group (P = .25). Infection was reported for 1 patient in the purse-string group and for 2 patients in the second intention group (P = .60). The only complication that reached statistical significance was spitting suture, which was observed in 8 surgical sites in the purse-string group (P = .004).

Place holder to copy figure label and caption
Figure.
Representative Scar Images at 3-Month Follow-up on the Dorsal Hand

Before (A) and after (D) images of second intention healing are shown compared with a wound before purse-string suture (B), the sutured wound (C), and follow-up scarring (E). Arrowhead indicates the evaluated scar in the purse-string group. Scar to defect ratios were similar in both arms of the study.

Graphic Jump Location
Table Graphic Jump LocationTable 3.  Secondary Outcome Measures
Table Graphic Jump LocationTable 4.  Complication Rates for Purse-String Suture vs Second Intention Healing

Our study found no significant differences in cosmetic outcomes as measured by blinded observers using the POSAS scale. Similarly, there were no significant differences in the secondary outcome measures of scar to defect ratio, pain, total patient POSAS score, and rate of complications.

Spitting suture was the only measured outcome with a significant difference in our study (P = .004) and requires no explanation. The difference in POSAS relief score might be attributable to tissue puckering that is observed following purse-string suture. The observed difference in healing time could result from the decreased wound aperture after purse-string suture. It is unclear whether these subgroup trends were the result of insufficient sample size or random variation that is expected with the use of multiple outcome measures.

Our findings regarding scar to defect size contrast with other studies, which suggested that purse-string suture may result in smaller-than-expected scars caused by other closure techniques.7,29 However, these other trials lacked comparator arms and assessments were unblinded. Consistent with other studies,5-8,15,18,28 purse-string suture reduced the postoperative defect size. However, this advantage was lost by the 3-month assessment. We attribute this finding to scars spreading with time in the purse-string group and wound contraction in the second intention group.

The conclusions of our study are strengthened by its a priori power analysis, randomized design with allocation concealment and blinded reviewers, and use of a validated outcome measure tool. Also, our 96% follow-up rate diminishes the chances of bias that might occur from patients excluded from analysis.

One limitation of our study was its single-center nature. Multiple sites would have expanded our study population and reduced the chances of sporadic findings. Furthermore, although the inclusion of multiple surgical sites (trunk and extremities) increases the external validity of our findings, we cannot exclude the possibility that certain anatomic locations might respond differently to purse-string suture. Although our primary outcome measure, the POSAS score, is a valid instrument, it is still subjective. Last, no in-person assessments were performed to assess wound healing. Not all patients may be able to recognize a fully healed scar.

Purse-string suture results in similar cosmetic outcomes, scar size, and pain level compared with second intention healing for circular or oval wounds on the torso or extremities. A statistical trend suggested that healing time might be faster in the purse-string arm and that scar relief at 3 months’ follow-up might be better in the second intention arm. A larger trial would help settle these 2 issues.

Accepted for Publication: July 10, 2014.

Corresponding Author: Daniel B. Eisen, MD, Department of Dermatology, University of California Davis Medical Center, 3301 C St, Ste 1400, Sacramento, CA 95816 (deisen123@gmail.com).

Published Online: November 5, 2014. doi:10.1001/jamadermatol.2014.2313.

Author Contributions: Drs Eisen and Armstrong had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

Study concept and design: Joo, Armstrong, King, Omlin, Kappel, Eisen.

Acquisition, analysis, or interpretation of data: Joo, Custis, Omlin, Kappel, Eisen.

Drafting of the manuscript: Joo, Armstrong, Omlin, Eisen.

Critical revision of the manuscript for important intellectual content: Joo, Custis, King, Omlin, Kappel, Eisen.

Statistical analysis: Armstrong.

Administrative, technical, or material support: Joo, Omlin.

Study supervision: King, Omlin, Eisen.

Conflict of Interest Disclosures: None reported.

Additional Contributions: We are indebted to Victoria Sharon, MD, Department of Dermatology, University of California Davis Medical Center, for her help with patient recruitment and Summer Youker, MD, for her help in planning the trial. Neither received financial compensation.

Peled  IJ, Zagher  U, Wexler  MR.  Purse-string suture for reduction and closure of skin defects. Ann Plast Surg. 1985;14(5):465-469.
PubMed   |  Link to Article
Cohen  PR, Martinelli  PT, Schulze  KE, Nelson  BR.  Closure of round cutaneous postoperative wounds with the purse string suture. South Med J. 2006;99(12):1401-1402.
PubMed   |  Link to Article
Cohen  PR, Martinelli  PT, Schulze  KE, Nelson  BR.  The purse-string suture revisited: a useful technique for the closure of cutaneous surgical wounds. Int J Dermatol. 2007;46(4):341-347.
PubMed   |  Link to Article
Zhu  JW, Wu  XJ, Lu  ZF, Cai  SQ, Zheng  M.  Purse-string suture for round and oval defects: a useful technique in dermatologic surgery. J Cutan Med Surg. 2012;16(1):11-17.
PubMed
Brady  JG, Grande  DJ, Katz  AE.  The purse-string suture in facial reconstruction. J Dermatol Surg Oncol. 1992;18(9):812-816.
PubMed   |  Link to Article
Greenbaum  SS, Radonich  MA.  The purse-string closure. Dermatol Surg. 1996;22(12):1054-1056.
PubMed   |  Link to Article
Mulliken  JB, Rogers  GF, Marler  JJ.  Circular excision of hemangioma and purse-string closure: the smallest possible scar. Plast Reconstr Surg. 2002;109(5):1544-1555.
PubMed   |  Link to Article
Yuen  JC.  Versatility of the subcuticular purse-string suture in wound closure. Plast Reconstr Surg. 1996;98(7):1302-1305.
PubMed   |  Link to Article
Cohen  PR, Martinelli  PT, Schulze  KE, Nelson  BR.  The cuticular purse string suture: a modified purse string suture for the partial closure of round postoperative wounds. Int J Dermatol. 2007;46(7):746-753.
PubMed   |  Link to Article
Jiang  C, Wang  M, Xu  Q, Wu  X, Yu  D, Ding  Y.  A modified technique for end-to-side pancreaticojejunostomy by purse-string suture. J Surg Oncol. 2011;104(7):852-856.
PubMed   |  Link to Article
Moreton  A, Shankar  S, Jones  S.  Randomized clinical trial of short-term outcomes following purse-string versus conventional closure of ileostomy wounds [comment on: Reid K, Pockney P, Pollitt T, Draganic B, Smith SR. Br J Surg. 2010;97:1511-1517]. Br J Surg. 2011;98(3):458.
PubMed   |  Link to Article
Addeo  P, Rosso  E, Fuchshuber  P,  et al.  Double purse-string telescoped pancreaticogastrostomy: an expedient, safe, and easy technique. J Am Coll Surg. 2013;216(3):e27-e33.
PubMed   |  Link to Article
Marconi  F.  The dermal pursestring suture: a new technique for a short inframammary scar in reduction mammaplasty and dermal mastopexy. Ann Plast Surg. 1989;22(6):484-494.
PubMed   |  Link to Article
Peled  IJ.  The concentric mastopexy and the purse-string suture. Plast Reconstr Surg. 1991;87(2):385.
PubMed   |  Link to Article
Karaci  S, Kose  R, Baykan  H, Ozkose  M.  Chain purse-string suture used to shorten the vertical incision in vertical breast reduction. Aesthetic Plast Surg. 2013;37(1):88-90.
PubMed   |  Link to Article
Romiti  R, Randle  HW.  Complete closure by purse-string suture after Mohs micrographic surgery on thin, sun-damaged skin. Dermatol Surg. 2002;28(11):1070-1072.
PubMed
Harrington  AC, Montemarano  A, Welch  M, Farley  M.  Variations of the pursestring suture in skin cancer reconstruction. Dermatol Surg. 1999;25(4):277-281.
PubMed   |  Link to Article
Ciatti  S, Greenbaum  SS.  Modified purse-string closure for reconstruction of moderate/large surgical defects of the face. Dermatol Surg. 1999;25(3):215-220.
PubMed   |  Link to Article
Weisberg  NK, Greenbaum  SS.  Revisiting the purse-string closure: some new methods and modifications. Dermatol Surg. 2003;29(6):672-676.
PubMed
Patel  KK, Telfer  MR, Southee  R.  A “round block” purse-string suture in facial reconstruction after operations for skin cancer surgery. Br J Oral Maxillofac Surg. 2003;41(3):151-156.
PubMed   |  Link to Article
Tremolada  C, Blandini  D, Beretta  M, Mascetti  M.  The “round block” purse-string suture: a simple method to close skin defects with minimal scarring. Plast Reconstr Surg. 1997;100(1):126-131.
PubMed   |  Link to Article
Hoffman  A, Lander  J, Lee  PK.  Modification of the purse-string closure for large defects of the extremities. Dermatol Surg. 2008;34(2):243-245.
PubMed   |  Link to Article
Cruz  AP, Campbell  RM, Perlis  CS, Dufresne  RG  Jr.  Double purse-string closure for scalp and extremity wounds. Dermatol Surg. 2007;33(3):369-373.
PubMed
Lin  H, Li  W.  Complete closure using a double purse-string closure for skin defects. Dermatol Surg. 2009;35(9):1406-1409.
PubMed   |  Link to Article
Zitelli  JA.  Secondary intention healing: an alternative to surgical repair. Clin Dermatol. 1984;2(3):92-106.
PubMed   |  Link to Article
Draaijers  LJ, Tempelman  FR, Botman  YA,  et al.  The patient and observer scar assessment scale: a reliable and feasible tool for scar evaluation. Plast Reconstr Surg. 2004;113(7):1960-1967.
PubMed   |  Link to Article
Random.org website.https://www.random.org/. Accessed June 9, 2013.
Harris  PA, Taylor  R, Thielke  R, Payne  J, Gonzalez  N, Conde  JG.  Research electronic data capture (REDCap): a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2009;42(2):377-381.
PubMed   |  Link to Article
Wu  JK, Rohde  CH.  Purse-string closure of hemangiomas: early results of a follow-up study. Ann Plast Surg. 2009;62(5):581-585.
PubMed   |  Link to Article

Figures

Place holder to copy figure label and caption
Figure.
Representative Scar Images at 3-Month Follow-up on the Dorsal Hand

Before (A) and after (D) images of second intention healing are shown compared with a wound before purse-string suture (B), the sutured wound (C), and follow-up scarring (E). Arrowhead indicates the evaluated scar in the purse-string group. Scar to defect ratios were similar in both arms of the study.

Graphic Jump Location

Tables

Table Graphic Jump LocationTable 2.  Results of POSAS Measurements
Table Graphic Jump LocationTable 3.  Secondary Outcome Measures
Table Graphic Jump LocationTable 4.  Complication Rates for Purse-String Suture vs Second Intention Healing

References

Peled  IJ, Zagher  U, Wexler  MR.  Purse-string suture for reduction and closure of skin defects. Ann Plast Surg. 1985;14(5):465-469.
PubMed   |  Link to Article
Cohen  PR, Martinelli  PT, Schulze  KE, Nelson  BR.  Closure of round cutaneous postoperative wounds with the purse string suture. South Med J. 2006;99(12):1401-1402.
PubMed   |  Link to Article
Cohen  PR, Martinelli  PT, Schulze  KE, Nelson  BR.  The purse-string suture revisited: a useful technique for the closure of cutaneous surgical wounds. Int J Dermatol. 2007;46(4):341-347.
PubMed   |  Link to Article
Zhu  JW, Wu  XJ, Lu  ZF, Cai  SQ, Zheng  M.  Purse-string suture for round and oval defects: a useful technique in dermatologic surgery. J Cutan Med Surg. 2012;16(1):11-17.
PubMed
Brady  JG, Grande  DJ, Katz  AE.  The purse-string suture in facial reconstruction. J Dermatol Surg Oncol. 1992;18(9):812-816.
PubMed   |  Link to Article
Greenbaum  SS, Radonich  MA.  The purse-string closure. Dermatol Surg. 1996;22(12):1054-1056.
PubMed   |  Link to Article
Mulliken  JB, Rogers  GF, Marler  JJ.  Circular excision of hemangioma and purse-string closure: the smallest possible scar. Plast Reconstr Surg. 2002;109(5):1544-1555.
PubMed   |  Link to Article
Yuen  JC.  Versatility of the subcuticular purse-string suture in wound closure. Plast Reconstr Surg. 1996;98(7):1302-1305.
PubMed   |  Link to Article
Cohen  PR, Martinelli  PT, Schulze  KE, Nelson  BR.  The cuticular purse string suture: a modified purse string suture for the partial closure of round postoperative wounds. Int J Dermatol. 2007;46(7):746-753.
PubMed   |  Link to Article
Jiang  C, Wang  M, Xu  Q, Wu  X, Yu  D, Ding  Y.  A modified technique for end-to-side pancreaticojejunostomy by purse-string suture. J Surg Oncol. 2011;104(7):852-856.
PubMed   |  Link to Article
Moreton  A, Shankar  S, Jones  S.  Randomized clinical trial of short-term outcomes following purse-string versus conventional closure of ileostomy wounds [comment on: Reid K, Pockney P, Pollitt T, Draganic B, Smith SR. Br J Surg. 2010;97:1511-1517]. Br J Surg. 2011;98(3):458.
PubMed   |  Link to Article
Addeo  P, Rosso  E, Fuchshuber  P,  et al.  Double purse-string telescoped pancreaticogastrostomy: an expedient, safe, and easy technique. J Am Coll Surg. 2013;216(3):e27-e33.
PubMed   |  Link to Article
Marconi  F.  The dermal pursestring suture: a new technique for a short inframammary scar in reduction mammaplasty and dermal mastopexy. Ann Plast Surg. 1989;22(6):484-494.
PubMed   |  Link to Article
Peled  IJ.  The concentric mastopexy and the purse-string suture. Plast Reconstr Surg. 1991;87(2):385.
PubMed   |  Link to Article
Karaci  S, Kose  R, Baykan  H, Ozkose  M.  Chain purse-string suture used to shorten the vertical incision in vertical breast reduction. Aesthetic Plast Surg. 2013;37(1):88-90.
PubMed   |  Link to Article
Romiti  R, Randle  HW.  Complete closure by purse-string suture after Mohs micrographic surgery on thin, sun-damaged skin. Dermatol Surg. 2002;28(11):1070-1072.
PubMed
Harrington  AC, Montemarano  A, Welch  M, Farley  M.  Variations of the pursestring suture in skin cancer reconstruction. Dermatol Surg. 1999;25(4):277-281.
PubMed   |  Link to Article
Ciatti  S, Greenbaum  SS.  Modified purse-string closure for reconstruction of moderate/large surgical defects of the face. Dermatol Surg. 1999;25(3):215-220.
PubMed   |  Link to Article
Weisberg  NK, Greenbaum  SS.  Revisiting the purse-string closure: some new methods and modifications. Dermatol Surg. 2003;29(6):672-676.
PubMed
Patel  KK, Telfer  MR, Southee  R.  A “round block” purse-string suture in facial reconstruction after operations for skin cancer surgery. Br J Oral Maxillofac Surg. 2003;41(3):151-156.
PubMed   |  Link to Article
Tremolada  C, Blandini  D, Beretta  M, Mascetti  M.  The “round block” purse-string suture: a simple method to close skin defects with minimal scarring. Plast Reconstr Surg. 1997;100(1):126-131.
PubMed   |  Link to Article
Hoffman  A, Lander  J, Lee  PK.  Modification of the purse-string closure for large defects of the extremities. Dermatol Surg. 2008;34(2):243-245.
PubMed   |  Link to Article
Cruz  AP, Campbell  RM, Perlis  CS, Dufresne  RG  Jr.  Double purse-string closure for scalp and extremity wounds. Dermatol Surg. 2007;33(3):369-373.
PubMed
Lin  H, Li  W.  Complete closure using a double purse-string closure for skin defects. Dermatol Surg. 2009;35(9):1406-1409.
PubMed   |  Link to Article
Zitelli  JA.  Secondary intention healing: an alternative to surgical repair. Clin Dermatol. 1984;2(3):92-106.
PubMed   |  Link to Article
Draaijers  LJ, Tempelman  FR, Botman  YA,  et al.  The patient and observer scar assessment scale: a reliable and feasible tool for scar evaluation. Plast Reconstr Surg. 2004;113(7):1960-1967.
PubMed   |  Link to Article
Random.org website.https://www.random.org/. Accessed June 9, 2013.
Harris  PA, Taylor  R, Thielke  R, Payne  J, Gonzalez  N, Conde  JG.  Research electronic data capture (REDCap): a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2009;42(2):377-381.
PubMed   |  Link to Article
Wu  JK, Rohde  CH.  Purse-string closure of hemangiomas: early results of a follow-up study. Ann Plast Surg. 2009;62(5):581-585.
PubMed   |  Link to Article

Correspondence

CME
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Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
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