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JAMA Dermatology Clinicopathological Challenge |

A Striking, Localized Eruption QUIZ

Amanda J. Tschetter, MD1; Mary S. Stone, MD1,2; Marta J. VanBeek, MD1
[+] Author Affiliations
1Department of Dermatology, University of Iowa Hospitals and Clinics, Iowa City
2Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City
JAMA Dermatol. 2014;150(11):1229-1230. doi:10.1001/jamadermatol.2014.2179.
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A, Large, reticulated, erythematous plaque with silvery scale localized to the mid-back. B-D, Punch biopsy specimens. B, Mild hyperkeratosis overlying an epidermis with dysmaturation and apoptotic cells, increased small blood vessels, pigment incontinence, and perivascular inflammation with lymphocytes and eosinophils (hematoxylin-eosin, original magnification ×20). C, Keratinocyte dysmaturation demonstrated by large keratinocytes with hyperchromatic nuclei and prominent nucleoli, and increased mitoses with starburst cells (arrowheads) (hematoxylin-eosin, original magnification ×60). D, Squamous metaplasia and apoptosis of the eccrine ducts (hematoxylin-eosin, original magnification ×60).

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