We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Editorial |

Cytophagic Histiocytic Panniculitis—a Critical Reappraisal

Mark R. Wick, MD; James W. Patterson, MD
Arch Dermatol. 2000;136(7):922-924. doi:10.1001/archderm.136.7.922.
Text Size: A A A
Published online


THE ASCENT and decline of concepts surrounding the cells known as histiocytes have been periodic phenomena for many years. Shortly after 1900, such elements were described under the rubric of "clasmatocytes" with the contention that they derived from peripheral blood leukocytes and emigrated from the bloodstream into tissue sites. Others likewise regarded them as "primitive wandering cells." In contrast, in their well-known and then-standard A Textbook of Pathology (first published in 1908), Beattie and Dickson1 offered the opinion that "histiohematogenous cells" were actually endothelial in character and originated from the lining cells of blood vessels and lymphatics. Sigal et al2 reported that Metchnikoff was the first to use the term macrophages in reference to the cells in question, in recognition that they were large (macro) cells that had the capacity to engulf (phagocytose) other cells, cellular debris, microorganisms, and foreign materials. He proposed that they were synonymous with "fixed tissue histiocytes" and felt that they were related to the latter in a functional schema, the macrophage system. Furthermore, Metchnikoff's construction was regarded as identical to the reticuloendothelial system, a term that had been coined in deference to the theory elucidated by Beattie and Dickson and others.

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

16 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Articles Related By Topic
Related Collections
PubMed Articles
The Role of Neutrophils in Alpha-1 Antitrypsin Deficiency. Ann Am Thorac Soc 2016;13 Suppl 4():S297-304.
Subcutaneous Fat Necrosis of the Newborn: A 20-Year Retrospective Study. Pediatr Dermatol Published online Aug 30, 2016;