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Correspondence | February 2000

Systemic Photodynamic Therapy Is a Safe and Effective Treatment for Psoriasis

Wolf-Henning Boehncke, MD; Thomas Elshorst-Schmidt, MD; Roland Kaufmann, MD

Arch Dermatol. 2000;136(2):271-272. doi:.

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Oral administration of 8-methoxypsoralen and irradiation with UV-A radiation (PUVA) is a well-established treatment regimen for psoriasis.¹ Evidence for an increased risk of malignant melanoma in PUVA-treated patients² prompted a dialogue as to whether PUVA should be abandoned for this indication.³ Photodynamic therapy (PDT) encompasses the therapeutic use of photochemical reactions mediated through the interaction of light, photosensitizing drugs, and oxygen. Demonstration of therapeutic efficacy using a polychromatic light source was an important step toward clinical application of PDT in the treatment of psoriasis.⁴

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Clinical response of patient 09. The psoriatic lesion evaluation score was 4 prior to therapy (top) and 2 at the completion of the study (bottom).

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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Boehncke W, Elshorst-Schmidt T, Kaufmann R. Systemic Photodynamic Therapy Is a Safe and Effective Treatment for Psoriasis. Arch Dermatol. 2000;136(2):271-272. doi:.

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