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Oral Mucosa Is Frequently Affected in Patients With Dermatitis Herpetiformis

Hannu Lähteenoja, MD, DDS; Kerttu Irjala, MD; Markku Viander, MD; Eeva Vainio, MD; Auli Toivanen, MD; Stina Syrjänen, DDS
Arch Dermatol. 1998;134(6):756-758. doi:.
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Dermatitis herpetiformis (DH) is a lifelong itching, blistering skin disease. Most patients have an associated gluten-sensitive enteropathy or coeliac disease (CDL)1 characterized histologically by duodenal and jejunal atrophy. It is well established that DH may affect the oral mucosa as well.23 According to previous reports,1,3 oral lesions are found in 1% to 10% of patients with DH, but Fraser and coworkers3 reported oral lesions in 70% of patients. In the present study, oral changes in DH were assessed.

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A buccal biopsy sample from a patient with dermatitis herpetiformis. With hematoxylin-eosin staining, lymphocytes are present in both the epithelium and lamina propria (A, original magnification ×100; B, original magnification ×40; and D, original magnification ×250). With the toluidine blue staining, mast cells are detected in the lamina propria (C, original magnification ×250).

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