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Research Letter |

Overview Photography and Short-term Mole Monitoring in Patients Taking a BRAF Inhibitor

Sarah Yagerman, MD1; Eileen Flores, MPH1; Klaus Busam, MD1; Mario Lacouture, MD1; Ashfaq A. Marghoob, MD1
[+] Author Affiliations
1Memorial Sloan-Kettering Skin Cancer Center, Hauppauge, New York
JAMA Dermatol. 2014;150(9):1010-1011. doi:10.1001/jamadermatol.2013.10413.
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Patients taking BRAF inhibitors develop new primary melanomas and nevi. Many of these neoplasms are BRAF wild-type,1 which may be due to the paradoxical activation of the RAF/MEK/ERK pathway via an alternative driver mutation, similar to the mechanism involved in inducing the development of squamous cell carcinomas in these patients.2 In addition, some nevi in these individuals involute,3 and many of these involuting lesions harbor a BRAFV600E (OMIM *164757) mutation.

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