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Cutaneous Hemophagocytosis After Alemtuzumab Injection in a Patient With Sézary Syndrome

Sarah I. Jawed, BA1,2; Klaus Busam, MD2,3; Xuan Wang, MD, PhD2,3; Steven Horwitz, MD2,4; Christiane Querfeld, MD, PhD1,2
[+] Author Affiliations
1Dermatology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York
2Weill Cornell Medical College, New York, New York
3Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York
4Lymphoma Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York
JAMA Dermatol. 2014;150(9):1021-1023. doi:10.1001/jamadermatol.2013.10615.
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Alemtuzumab, a CD52 monoclonal antibody, is increasingly used for treating advanced cutaneous T-cell lymphomas including Sézary syndrome (SS). While injection site reactions are common, the finding of localized cutaneous hemophagocytosis at the injection site without systemic hemophagocytosis is rare.

Article InformationCorresponding Author: Christiane Querfeld, MD, PhD, Dermatology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, 160 E 53rd St, New York, NY 10022 (querfelc@mskcc.org).

Published Online: July 16, 2014. doi:10.1001/jamadermatol.2013.10615.

Conflict of Interest Disclosures: None reported.

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Clinical and Pathologic Images From a Case of Cutaneous Hemophagocytosis After Subcutaneous Alemtuzumab Injection

A, Clinical image of erythematous to brown indurated plaque on right lateral thigh following subcutaneous injection with alemtuzumab. B, Pathologically, a deep dermal infiltrate consisting of histiocytes, neutrophils, extravasated erythrocytes, and scattered atypical lymphocytes was present; histiocytes with phagocytosed neutrophils, lymphocytes, and erythrocytes were seen (hemophagocytosis; arrowheads) (hematoxylin-eosin, original magnification ×400).

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