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Cutaneous Embolization of Doxorubicin Drug-Eluting Beads

Elizabeth Grieshaber, MD1; Thomas Nicotri, MD1; Rachel Reina, MD2; Katherine Rupley, BS3; Alun Wang, MD, PhD4
[+] Author Affiliations
1Department of Dermatology, Louisiana State University Health Sciences Center, New Orleans
2Baldone Reina Dermatology, Covington, Louisiana
3Louisiana State University Health Sciences Center, New Orleans
4Dermatopathology Section, Department of Pathology and Laboratory Medicine, Tulane University Health Sciences, Tulane University School of Medicine, New Orleans, Louisiana
JAMA Dermatol. 2014;150(10):1118-1120. doi:10.1001/jamadermatol.2014.305.
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Transarterial chemoembolization (TACE) with drug-eluting microspheres (DEMs) is emerging as the therapy of choice by many interventional oncologists and radiologists for unresectable liver tumors. Improvements in drug delivery systems have been made by modification of the embolic agents and the introduction of microcatheters, allowing for precise drug delivery to tumors. Currently, DEMs are being used as the drug delivery system for TACE.1 We report herein a case of cutaneous embolization of doxorubicin-impregnated DEMs after DEM TACE treatment for breast carcinoma metastasized to the liver.

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Figure.
Doxorubicin Drug Embolization

A, The clinical presentation shows cutaneous retiform erythematous papules, few with ulceration, after transarterial chemoembolization with drug-eluting microspheres (DEM). B, The histopathologic findings show a foreign material, thought to be a component of DEM, within a vessel of adipose tissue (hematoxylin-eosin, original magnification ×40). This finding was supported by x-ray analysis (not shown).

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