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Eczematous Reaction to Intravenous Immunoglobulin An Alternative Cause of Eczema FREE

Julia Miyamoto, MD, PhD1,2; Barbara C. Böckle, MD2; Detlef Zillikens, MD3; Enno Schmidt, MD, PhD3; Matthias Schmuth, MD2
[+] Author Affiliations
1Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
2Department of Dermatology and Venereology, Innsbruck Medical University, Innsbruck, Austria
3Department of Dermatology, University of Luebeck, Luebeck, Germany
JAMA Dermatol. 2014;150(10):1120-1122. doi:10.1001/jamadermatol.2014.109.
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Published online

REPORT OF A CASE

A man in his 70s presented with eczematous plaques on his face, trunk, and extremities, including erythema, fissures, and scales on his palms and soles (Figure 1). There were no blisters, erosions, or any mucosal lesions. The patient’s medical history revealed peripheral neuropathy due to Waldenström macroglobulinemia. Several days prior to the onset of skin lesions, he had been treated with high-dose intravenous immunoglobulin (IVIG) (Intratect; Biotest), 1g/kg/d for 2days, for control of his neuropathy. There was no history of IVIG treatment, atopic dermatitis, respiratory allergies, and/or asthma. His other medications at that time, which had remained unchanged for at least 2 years, consisted of acetylsalicylic acid, simvastatin, and tamsulosin.

Place holder to copy figure label and caption
Figure 1.
Clinical Images of Eczematous Skin Lesions

Lesions presented on the trunk (A), palms (B), and lower extremities (C).

Graphic Jump Location

A skin biopsy was performed on lesional skin. Histologic analysis showed spongiosis and lymphocytic infiltrates (Figure 2A). No acantholysis was present. Direct immunofluorescent (IF) microscopy showed intercellular deposits of C3 throughout the epidermis and granular depositions along the basement membrane (Figure 2B), but no IgG or IgA was detected. Indirect IF microscopy showed intercellular IgG deposits on monkey esophagus (Figure 2C) but not in rat or monkey bladder epithelium. No IgA deposits were detected in these tissues.

Place holder to copy figure label and caption
Figure 2.
Skin Biopsy Specimens

A, Spongiosis and inflammatory infiltrates were found on histologic analysis (hematoxylin-eosin, original magnification ×40). B, Intercellular epidermal C3 deposits seen on direct immunofluorescence (IF) microscopy (original magnification ×80). C, Intercellular epidermal IgG deposits on indirect IF microscopy using monkey esophagus (original magnification ×40).

Graphic Jump Location

No serum antibodies against desmoglein-1, desmoglein-3, desmocollin-1, or envoplakin were detected by enzyme-linked immunosorbent assay or indirect IF microscopy on transfected HEK293 cells (Euroimmun). Findings of serum antinuclear antibody titers were negative. Initially, topical corticosteroids (class III and subsequently class II) and skin emollients were administered, but the skin lesions persisted.

After switching his treatment regimen to oral methylprednisolone (0.3 mg/kg/d), the patient’s skin lesions cleared within 2 weeks. Following tapering and without any further treatment, no recurrence was observed during a follow-up of 3 years. Further IVIG therapy has been withheld despite persisting neuropathy.

DISCUSSION

One of the differential diagnoses of intercellular deposits of C3 in the epidermis and circulating pemphigus-like IgG autoantibodies is paraneoplastic pemphigus (PNP), but PNP has oral mucosal lesions and is very recalcitrant. Although our patient did not exhibit oral lesions, his eruption quickly responded to oral methylprednisolone. No serum antibodies against envoplakin were detected. Therefore, atypical pemphigus, characterized by antibodies against desmocollins with or without anti-desmoglein reactivity,1,2 was considered among the differential diagnoses. However, this disease usually demonstrates vesicular or erosive lesions.

Based on clinical examination, direct and indirect IF microscopy, and histologic and laboratory findings, we diagnosed an eczematous reaction due to IVIG treatment. This reaction is often pronounced on the palms and soles (eg, presenting as pompholyx). Usually, topical steroids are effective treatment, but occasionally oral steroids are necessary. In a case series, 13 of 64 patients with this diagnosis underwent skin biopsy.3 However, to our knowledge, antibodies against epidermal antigens, as in our case, have not been previously reported.

The pathogenesis of the eczematous reaction to IVIG is unknown. Serum complement consumption was reported by Sarmiento et al.4 The epidermal complement deposits in our patient may provide an explanation: IVIG can act in a manner analogous to a B-cell superantigen; ie, B cells are activated following IVIG therapy.5,6 We therefore speculate that activated B cells may produce the antibodies against epidermal antigens. It is unclear why these antibodies were not blister inducing. One possible explanation is that the titer of these circulating autoantibodies was too low.

In conclusion, we report a case of eczema following IVIG treatment for neuropathy caused by Waldenström macroglobulinemia in which for the first time we describe detection of circulating autoantibodies against epidermal antigens in patient serum.

ARTICLE INFORMATION

Corresponding Author: Matthias Schmuth, MD, Department of Dermatology and Venereology, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria (matthias.schmuth@i-med.ac.at).

Published Online: June 25, 2014. doi:10.1001/jamadermatol.2014.109.

Conflict of Interest Disclosures: None reported.

Additional Contributions: We are indebted to Robert Zangerle, MD, Department of Dermatology and Venereology, Innsbruck Medical University, for valuable discussions and to Lisa Wackerle, Department of Dermatology and Venereology, Innsbruck Medical University, for excellent editorial assistance. These contributors received no compensation beyond that provided in the normal course of their employment.

REFERENCES

Endo  Y, Tsujioka  K, Tanioka  M,  et al.  Bullous dermatosis associated with IgG antibodies specific for desmocollins. Eur J Dermatol. 2010;20(5):620-625.
PubMed
Müller  R, Heber  B, Hashimoto  T,  et al.  Autoantibodies against desmocollins in European patients with pemphigus. Clin Exp Dermatol. 2009;34(8):898-903.
PubMed   |  Link to Article
Gerstenblith  MR, Antony  AK, Junkins-Hopkins  JM, Abuav  R.  Pompholyx and eczematous reactions associated with intravenous immunoglobulin therapy. J Am Acad Dermatol. 2012;66(2):312-316.
PubMed   |  Link to Article
Sarmiento  E, Micheloud  D, Carbone  J.  Complement consumption associated with eczematous cutaneous reaction during infusions of high doses of intravenous immunoglobulin. Br J Dermatol. 2004;151(3):721.
PubMed   |  Link to Article
Osei  A, Uttenreuther-Fischer  MM, Lerch  H, Gaedicke  G, Fischer  P.  Restricted VH3 gene usage in phage-displayed Fab that are selected by intravenous immunoglobulin. Arthritis Rheum. 2000;43(12):2722-2732.
PubMed   |  Link to Article
Leucht  S, Uttenreuther-Fischer  MM, Gaedicke  G, Fischer  P.  The B cell superantigen-like interaction of intravenous immunoglobulin (IVIG) with Fab fragments of V(H) 3-23 and 3-30/3-30.5 germline gene origin cloned from a patient with Kawasaki disease is enhanced after IVIG therapy. Clin Immunol. 2001;99(1):18-29.
PubMed   |  Link to Article

Figures

Place holder to copy figure label and caption
Figure 1.
Clinical Images of Eczematous Skin Lesions

Lesions presented on the trunk (A), palms (B), and lower extremities (C).

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.
Skin Biopsy Specimens

A, Spongiosis and inflammatory infiltrates were found on histologic analysis (hematoxylin-eosin, original magnification ×40). B, Intercellular epidermal C3 deposits seen on direct immunofluorescence (IF) microscopy (original magnification ×80). C, Intercellular epidermal IgG deposits on indirect IF microscopy using monkey esophagus (original magnification ×40).

Graphic Jump Location

Tables

References

Endo  Y, Tsujioka  K, Tanioka  M,  et al.  Bullous dermatosis associated with IgG antibodies specific for desmocollins. Eur J Dermatol. 2010;20(5):620-625.
PubMed
Müller  R, Heber  B, Hashimoto  T,  et al.  Autoantibodies against desmocollins in European patients with pemphigus. Clin Exp Dermatol. 2009;34(8):898-903.
PubMed   |  Link to Article
Gerstenblith  MR, Antony  AK, Junkins-Hopkins  JM, Abuav  R.  Pompholyx and eczematous reactions associated with intravenous immunoglobulin therapy. J Am Acad Dermatol. 2012;66(2):312-316.
PubMed   |  Link to Article
Sarmiento  E, Micheloud  D, Carbone  J.  Complement consumption associated with eczematous cutaneous reaction during infusions of high doses of intravenous immunoglobulin. Br J Dermatol. 2004;151(3):721.
PubMed   |  Link to Article
Osei  A, Uttenreuther-Fischer  MM, Lerch  H, Gaedicke  G, Fischer  P.  Restricted VH3 gene usage in phage-displayed Fab that are selected by intravenous immunoglobulin. Arthritis Rheum. 2000;43(12):2722-2732.
PubMed   |  Link to Article
Leucht  S, Uttenreuther-Fischer  MM, Gaedicke  G, Fischer  P.  The B cell superantigen-like interaction of intravenous immunoglobulin (IVIG) with Fab fragments of V(H) 3-23 and 3-30/3-30.5 germline gene origin cloned from a patient with Kawasaki disease is enhanced after IVIG therapy. Clin Immunol. 2001;99(1):18-29.
PubMed   |  Link to Article

Correspondence

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