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Primary Cutaneous Follicle Center Lymphoma With Follicular Mucinosis

Maria C. Garrido, MD, PhD1; Erica Riveiro-Falkenbach, MD, PhD1; Jose Luis Rodriguez-Peralto, MD, PhD1
[+] Author Affiliations
1Department of Pathology, Hospital Universitario 12 de Octubre, Universidad Complutense, Instituto de Investigación I+12, Madrid, Spain
JAMA Dermatol. 2014;150(8):906-907. doi:10.1001/jamadermatol.2013.9060.
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Follicular mucinosis (FM) is defined as the accumulation of a mucinous material within the hair follicle. Since its first description by Pinkus1 in 1957 in the setting of alopecia mucinosa, 2 main forms have been classically recognized: a benign idiopathic form, primary follicular mucinosis (PFM), which usually appears in young adults and regresses spontaneously; and a secondary form, lymphoma-associated follicular mucinosis (LAFM),2 which mostly occurs in elderly patients. Most cases of LAFM are related to cutaneous T-cell lymphomas (especially mycosis fungoides), although some cases of Hodgkin disease3 and chronic lymphocytic leukemia4 have also been reported.

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Figure 1.
A Case of Primary Cutaneous Follicle Center Lymphoma With a Very Unusual Miliary Clinical Presentation

Multiple, diffuse, pruritic, skin-colored papules show a follicular pattern on the chest.

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Figure 2.
Histologic Specimens From Primary Cutaneous Follicle Center Lymphoma With Follicular Mucinosis

A, High-magnification image showing follicular mucinosis and follicular tropism of the atypical lymphocytes (hematoxylin-eosin, original magnification ×100). B, Dense CD20+ lymphoid proliferation around and within the pilosebaceous unit (CD20 staining, original magnification ×100).

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Follicular mucinosis - case report. An Bras Dermatol 2014 Mar-Apr;89(2):337-9.
Primary Cutaneous Follicle Center Lymphoma With Follicular Mucinosis. JAMA Dermatol Published online Jun 18, 2014.;
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