A woman in her 50s with an approximately 20 pack-year smoking history experienced a myocardial infarction, prompting anticoagulation therapy with heparin, cardiac catheterization, and stent placement at an outside hospital. Postoperatively, she initiated aspirin and clopidogrel treatment. Seven days after initiation, her lower back, buttocks, and thighs developed painful erythematous plaques, which progressed to nodules and ulcerations over days to weeks. A biopsy performed at the outside hospital suggested vasculitis. Prednisone treatment was initiated, and clopidogrel therapy was discontinued. As her ulcers continued to enlarge and her proximal arms developed mottling, she was referred to our clinic for evaluation.