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Research Letter |

Further Investigation Into the Risk of Skin Cancer Associated With the Use of UV Nail Lamps FREE

Lyndsay R. Shipp, MD1; Catherine A. Warner, MD1; Frederick A. Rueggeberg, DDS, MS1; Loretta S. Davis, MD1
[+] Author Affiliations
1Division of Dermatology, Department of Medicine, Medical College of Georgia and College of Dental Medicine at Georgia Regents University, Augusta
JAMA Dermatol. 2014;150(7):775-776. doi:10.1001/jamadermatol.2013.8740.
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Published online

Use of UV radiation in nail salons for drying and curing polishes has come under scrutiny owing to concerns for carcinogenesis.1,2 A few recent studies evaluated potential irradiation scenarios and concluded that UV nail polish drying lamps pose only a small risk to clients.3 However, these studies lacked randomized light sampling from commercial salons.

We conducted a small study based on random UV light sampling in nail salons in 2 geographic locations to evaluate the unweighted UV-A and UV-B irradiance of a variety of nail polish drying devices. Our study differed from those previously published by highlighting the variety of UV light lamps used in commercial nail salons as well as the varying UV irradiance emitted within each individual device. Finally, we evaluated the risk to the user by comparing median irradiance with an energy density of UV-A shown to cause DNA damage.

Because nail polish drying lamps primarily emit UV-A, we chose to use the UV-A/UV-B light meter by Sper Scientific (model No. 850009), which measures primarily the spectrum of 280 to 400 nm.4 Using this meter, drying lamp devices within a sample of commercial salons were tested. The median irradiance was measured from 5 different positions within each device to take into account potential different hand positions by the client.5 The numbers of light elements, as well as the wattage, were recorded for each device. Statistical analysis was performed using the Shapiro-Wilks test; however, the data failed normality testing because the local irradiance values of the 5 different positions were not homogeneous. Therefore, Kruskal-Wallis 1-way analysis of variance on Spearman rank coefficients was performed, using the Tukey test for post hoc, pair-wise median comparisons. Statistical testing was performed at a preset alpha of α = .05. Institutional review board approval was waived because human participants were not involved in the study.

Seventeen different light sources from 16 salons demonstrated a wide range of light source brands, bulb wattages, and number of bulbs per device. Higher-wattage sources correlated with higher UV-A irradiance emitted (Figure). The energy density delivered per light based on the median UV-A irradiance measured was calculated. Comparing these numbers with 600 kJ/m2 (60J/cm2), the energy density shown to cause DNA damage in UV-A–irradiated keratinocytes, we showed that longer exposure times led to increased potential for cutaneous damage (Table).4,6,7

Place holder to copy figure label and caption
Figure.
Median Irradiance (UV-A) of a Variety of Nail Polish Drying Devices

Of the 17 light units tested, a wide range of wattages, number of bulbs, and median irradiance values was found. The data indicate a direct correlation between the increasing wattage of the light bulb and the amount of UV-A irradiance emitted.

Graphic Jump Location
Table Graphic Jump LocationTable.  Number of Nail Salon Visits and the Risk for DNA Damagea

This study revealed 3 important conclusions not addressed in previous publications. First, to our knowledge, random sampling of commercial nail polish drying devices has not been previously performed to determine if a difference in UV-A irradiance exists. We found notable differences in UV-A irradiance values among the 17 drying devices tested. Second, the UV-A irradiance in different areas of potential hand placement within drying devices has not been measured to determine relative homogeneity. This study demonstrated that the irradiance values were not normally distributed within each light device. Specifically, given the varying results when the detector head was placed in 5 different places within the hand-exposure area, it may be assumed that, although not directly measured, the irradiance values were not uniformly distributed over the entire area of potential exposure. Finally, the original publications assumed the UV-A energy exposure from commercial5 nail polish drying devices would fall within the estimated range determined to be potentially carcinogenic.1,2,4 However, considering the low UV-A energy exposure in an average manicure visit, multiple visits would be required to reach the threshold for potential DNA damage. Although the in vivo risk from multiple manicure visits remains untested, our data suggest that, even with numerous exposures, the risk for carcinogenesis remains small. That said, we concur with previous authors in recommending use of physical blocking sunscreens or UV-A protective gloves to limit the risk of carcinogenesis and photoaging.

Corresponding Author: Lyndsay R. Shipp, MD, Division of Dermatology, Department of Medicine, Medical College of Georgia at Georgia Regents University, 1004 Chafee Ave, FH-100, Augusta, GA 30904 (lshipp@gru.edu).

Accepted for Publication: September 22, 2013

Published Online: April 30, 2014. doi:10.1001/jamadermatol.2013.8740.

Author Contributions: Dr Shipp had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Study concept and design: Shipp, Warner, Davis.

Acquisition, analysis, or interpretation of data: Shipp, Warner, Rueggeberg.

Drafting of the manuscript: Shipp, Warner, Rueggeberg.

Critical revision of the manuscript for important intellectual content: Shipp, Rueggeberg, Davis.

Statistical analysis: Warner, Rueggeberg.

Administrative, technical, or material support: All authors.

Study supervision: Davis.

Conflict of Interest Disclosures: None reported.

Correction: This article was corrected online June 19, 2014, for errors in the Table.

MacFarlane  DF, Alonso  CA.  Occurrence of nonmelanoma skin cancers on the hands after UV nail light exposure. Arch Dermatol. 2009;145(4):447-449.
PubMed   |  Link to Article
Markova  A, Weinstock  MA.  Risk of skin cancer associated with the use of UV nail lamp. J Invest Dermatol. 2013;133(4):1097-1099.
PubMed   |  Link to Article
Schoon  D, Bryson  P, McConnell  J. Do UV nail lamps emit unsafe levels of ultraviolet light? three experts refute claims that UV nail lamps are unsafe for skin. http://www.schoonscientific.com/downloads/UV-Nail-Lamp-Facts.pdf. Accessed September 7, 2013.
Diffey  BL.  The risk of squamous cell carcinoma in women from exposure to UVA lamps used in cosmetic nail treatment. Br J Dermatol. 2012;167(5):1175-1178.
PubMed   |  Link to Article
Commission Internationale de l’Eclairage. CIE S 007/E-1998: Erythema Reference Action Spectrum and Standard Erythema Dose. Vienna, Austria: CIE Standard; 1998.
Greinert  R, Volkmer  B, Henning  S,  et al.  UV-A–induced DNA double-strand breaks result from the repair of clustered oxidative DNA damages. Nucleic Acid Res.2012;40(20):10263-10273.
Link to Article
Wischermann  K, Popp  S, Moshir  S,  et al.  UV-A radiation causes DNA strand breaks, chromosomal aberrations and tumorigenic transformation in HaCaT skin keratinocytes. Oncogene. 2008;27(31):4269-4280.
PubMed   |  Link to Article

Figures

Place holder to copy figure label and caption
Figure.
Median Irradiance (UV-A) of a Variety of Nail Polish Drying Devices

Of the 17 light units tested, a wide range of wattages, number of bulbs, and median irradiance values was found. The data indicate a direct correlation between the increasing wattage of the light bulb and the amount of UV-A irradiance emitted.

Graphic Jump Location

Tables

Table Graphic Jump LocationTable.  Number of Nail Salon Visits and the Risk for DNA Damagea

References

MacFarlane  DF, Alonso  CA.  Occurrence of nonmelanoma skin cancers on the hands after UV nail light exposure. Arch Dermatol. 2009;145(4):447-449.
PubMed   |  Link to Article
Markova  A, Weinstock  MA.  Risk of skin cancer associated with the use of UV nail lamp. J Invest Dermatol. 2013;133(4):1097-1099.
PubMed   |  Link to Article
Schoon  D, Bryson  P, McConnell  J. Do UV nail lamps emit unsafe levels of ultraviolet light? three experts refute claims that UV nail lamps are unsafe for skin. http://www.schoonscientific.com/downloads/UV-Nail-Lamp-Facts.pdf. Accessed September 7, 2013.
Diffey  BL.  The risk of squamous cell carcinoma in women from exposure to UVA lamps used in cosmetic nail treatment. Br J Dermatol. 2012;167(5):1175-1178.
PubMed   |  Link to Article
Commission Internationale de l’Eclairage. CIE S 007/E-1998: Erythema Reference Action Spectrum and Standard Erythema Dose. Vienna, Austria: CIE Standard; 1998.
Greinert  R, Volkmer  B, Henning  S,  et al.  UV-A–induced DNA double-strand breaks result from the repair of clustered oxidative DNA damages. Nucleic Acid Res.2012;40(20):10263-10273.
Link to Article
Wischermann  K, Popp  S, Moshir  S,  et al.  UV-A radiation causes DNA strand breaks, chromosomal aberrations and tumorigenic transformation in HaCaT skin keratinocytes. Oncogene. 2008;27(31):4269-4280.
PubMed   |  Link to Article

Correspondence

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