Accepted for Publication: December 3, 2013.
Published Online: April 23, 2014. doi:10.1001/jamadermatol.2013.10099.
Study concept and design: Watanabe, Fisher, Kupper, Clark.
Acquisition of data: Watanabe, Teague, Fisher, Kupper.
Analysis and interpretation of data: Watanabe, Teague, Kupper, Clark.
Drafting of the manuscript: Clark.
Critical revision of the manuscript for important intellectual content: Watanabe, Teague, Fisher, Kupper, Clark.
Statistical analysis: Kupper.
Obtained funding: Kupper, Clark.
Administrative, technical, or material support: Teague, Fisher, Kupper.
Study supervision: Fisher, Clark.
Conflict of Interest Disclosures: Drs Kupper and Clark previously had an equity interest in TremRX, a start-up company that seeks as a long-term business plan to improve vaccine formulation and delivery. During the period Drs Kupper and Clark held the equity, the interest was deemed to create a financial conflict of interest (as defined by the specific Public Health Service regulations) with the research discussed in this article. To resolve this matter, Drs Kupper and Clark divested themselves of the equity interest in this company, so this financial conflict of interest no longer exists. Dr Clark has served as a Scientific Advisor for Novartis and Stiefel Laboratories and received honoraria for these services. No other disclosures are reported.
Funding/Support: This study was supported in part by a Special Fellow Award from the Leukemia & Lymphoma Society (Dr Watanabe); SPORE in Skin Cancer grant P50 CA9368305 from the National Institutes of Health (NIH)/National Cancer Institute (Dr Kupper); NIH/National Institute of Allergy and Infectious Diseases grant R01 A1025082 (Dr Kupper); NIH grant R01 AI097128 (Drs Kupper and Clark); a generous charitable contribution from Edward P. Lawrence, Esq; a Damon Runyon Cancer Research Foundation Clinical Investigator Award (Dr Clark); NIH/National Institute of Arthritis, Musculoskeletal, and Skin Diseases (NIAMS) grants R01 AR056720 and R01 AR063962 (Dr Clark); and NIH/National Institute of Mental Health (NIMH) grant R03 MH095529 (Dr Clark).
Role of the Sponsor: None of the funders had any role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: We are indebted to the patients who made this work possible, both for entrusting us with their clinical care and for donating skin and blood samples.