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True Leukonychia in Crohn Disease Induced by Selenium Deficiency

Naoko Hasunuma, MD, PhD1,2; Yoshihiro Umebayashi, MD, PhD2; Motomu Manabe, MD, PhD2
[+] Author Affiliations
1Department of Community Medicine and Primary Care Development, Akita University School of Medicine, Akita, Japan
2Department of Dermatology and Plastic Surgery, Akita University Graduate School of Medicine, Akita, Japan
JAMA Dermatol. 2014;150(7):779-780. doi:10.1001/jamadermatol.2013.6701.
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Leukonychia is divided into 2 major types: true leukonychia, which involves the nail plate, and apparent leukonychia, which involves the nail bed.1 Herein, we present the first case to our knowledge of true leukonychia successfully treated with selenium substitution.

Article InformationCorresponding Author: Naoko Hasunuma, MD, PhD, Department of Community Medicine and Primary Care Development, Akita University School of Medicine, Hondo1-1-1, Akita, Akita, 010-8543 Japan (matsunao@med.akita-u.ac.jp).

Published Online: March 26, 2014. doi:10.1001/jamadermatol.2013.6701.

Conflict of Interest Disclosures: None reported.

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Figure.
Clinical Photographs of the Affected Patient

A, Leukonychia before selenium substitution manifests as whitish proximal fingernail halves, while the distal halves are normal, and on each nail, the 2 color zones are sharply demarcated. B, After 8 weeks of selenium substitution, the whitish halves of the fingernails have moved toward the distal portions. C, After 14 weeks of selenium substitution, the nail conditions have turned normal.

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