We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
JAMA Dermatology a Century Ago |

Etiology of Variola and Vaccines

Mark Bernhardt, MD
JAMA Dermatol. 2014;150(3):237. doi:10.1001/jamadermatol.2013.8189.
Text Size: A A A
Published online


Box Section Ref ID

The Journal of Cutaneous Diseases

March 1914


(Oct. 30, 1913, xxxix, No. 44.)

Abstracted by Clarence Allen Baer, M.D.


The author has demonstrated bodies in the serum and pus taken from variola lesions. These bodies are small, round, sharply defined bodies like cocci. They are often in pairs, connected by a filament. The two little bodies dance around each other. The bodies are often surrounded by a capsule. They pass through a Berkefeld filter, stain with difficulty and are easily decolorized. The bodies are under one-half micron in size. The organisms are intracellular and are found in the epithelial cells. Some cells show vacuoles containing a few bodies while others are packed full of the bodies. The bodies are resistant—they are not soluble in 2 per cent. potassium hydrate, 2 per cent. acetic acid, chloroform, ether, alcohol and are agglutinated by a specific serum. Paschen claims these bodies as the cause of variola because of the constancy of their presence, their large numbers in the lesions and their absence in other skin pustules. The organism has not been cultivated.

J Cutan Dis. 1914;32(3):249-250.

Figures in this Article


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.