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JAMA Dermatology Clinicopathological Challenge |

Odd-Looking Hair and Progressive Alopecia in Mother and Son QUIZ

Annette Kolb-Mäurer, MD, PhD1; Regina C. Betz, MD2; Henning Hamm, MD1
[+] Author Affiliations
1Department of Dermatology, Venereology, and Allergology, University Hospital Würzburg, Würzburg, Germany
2Institute of Human Genetics, University of Bonn, Bonn, Germany
JAMA Dermatol. 2014;150(5):567-568. doi:10.1001/jamadermatol.2013.8078.
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Clinical and microscopic photographs. A, Scalp hair of the son is dark, stiff, and rough; hair loss in the parieto-occipital region is evident, as are the sparse eyebrows and eyelashes. B, Ill-defined hair loss in the right parieto-occipital region shows a 4 × 2-cm, almost hairless area with pebbly scalp surface and diminished follicular openings. C, Light microscopy of scalp hair from both patients reveals deeply pigmented shafts with various diameters and structural abnormalities (original magnification × 40).

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