Observation |

Treatment of Giant Cellulitis-like Sweet Syndrome With Dapsone

Hideki Koketsu, MD1; Carlos Ricotti, MD1; Francisco A. Kerdel, BSc, MBBS1
[+] Author Affiliations
1Florida Academic Dermatology Centers, Miami
JAMA Dermatol. 2014;150(4):457-459. doi:10.1001/jamadermatol.2013.7814.
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Sweet syndrome is an inflammatory condition characterized by the abrupt development of erythematous plaques accompanied by fever and neutrophilia. Different clinical presentations of this disorder have been described1 in the literature. We read with interest a recent report in JAMA Dermatology2 describing a new clinical variant of Sweet syndrome, namely, giant cellulitis-like Sweet syndrome. Clinically these patients develop large, red erythematous plaques that recur and often are misdiagnosed as cellulitis but are not responsive to systemic antibiotic therapy. However, these plaques respond to systemic corticosteroid therapy.

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Figure 1.
A Case of Giant Cellulitis-like Sweet Syndrome

Large erythematous/edematous plaque over the patient’s thigh and flank.

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Figure 2.
Results of Treatment With Dapsone for Giant Cellulitis-like Sweet Syndrome

The lesion resolved with some postinflammatory pigment alterations.

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[Histological and clinical forms of the eosinophilic cellulitis]. Ann Dermatol Venereol 2001;128(3 Pt 1):213-6.
Treatment of Giant Cellulitis-like Sweet Syndrome With Dapsone. JAMA Dermatol Published online Feb 26, 2014.;