A variety of reported treatments have demonstrated some degree of success, including topical retinoids, fluorouracil cream, 5% imiquimod cream, and topical vitamin D analogues. Treatment with oral retinoids has also proved beneficial, yet disease often recurs after discontinuation of therapy.3 Destructive options more appropriate for local variants include excision, cryotherapy with liquid nitrogen, dermabrasion, and chemical peels. In addition, a variety of laser therapies and photodynamic therapy have shown variable efficacy. These destructive, surgical, and laser therapies are not suitable for widespread disease, however, because they cause scarring and pain. Because recurrence is common with the treatment options currently available for disseminated disease, alternative therapies are necessary, and because several of the conventional treatments for porokeratosis had been tried without success in our patient, we tried using a novel therapy.