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Research Letter |

Long-term Safety of Topical Pimecrolimus and Topical Tacrolimus in Atopic Blepharoconjunctivitis

Ville Kiiski, MD1; Anita Remitz, MD, PhD1; Sakari Reitamo, MD, PhD1; Johanna Mandelin, MD, PhD1; Osmo Kari, MD, PhD1
[+] Author Affiliations
1Skin and Allergy Hospital of Helsinki University Central Hospital, Helsinki, Finland
JAMA Dermatol. 2014;150(5):571-574. doi:10.1001/jamadermatol.2013.7016.
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Atopic blepharoconjunctivitis (ABC) is an ocular manifestation of atopy with a course similar to that of atopic dermatitis: chronic with exacerbations. Topical corticosteroids are widely used for ABC, but long-term use has a well-established risk of adverse effects: increase of intraocular pressure (IOP) or glaucoma, subcapsular cataract, reactivation of herpes simplex virus, and skin atrophy.1,2 Some of the adverse effects may manifest in a matter of days in susceptible individuals (IOP increase), while some are relevant in prolonged use (skin atrophy and subcapsular cataract). Topical calcineurin inhibitors pimecrolimus and tacrolimus have shown good long-term safety in the treatment of atopic dermatitis,3 and previous smaller studies of the use of tacrolimus on the eyelids have shown good safety, efficacy, improvement of conjunctival cytology, and a positive effect on IOP.46

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