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Original Investigation |

Retreatment With Omalizumab Results in Rapid Remission in Chronic Spontaneous and Inducible Urticaria

Martin Metz, MD1; Tatevik Ohanyan, MD1; Martin K. Church, PhD, DSc1; Marcus Maurer, MD1
[+] Author Affiliations
1Department of Dermatology, Venerology, and Allergology, Allergie-Centrum-Charité, Charité-Universitätsmedizin Berlin, Berlin, Germany
JAMA Dermatol. 2014;150(3):288-290. doi:10.1001/jamadermatol.2013.8705.
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Importance  Omalizumab has emerged as a novel and effective treatment option for patients with antihistamine-resistant chronic urticaria. It is unclear whether patients with recurrent urticaria symptoms after discontinuation of omalizumab treatment can benefit from retreatment.

Objective  To assess the response of patients with chronic urticaria who receive omalizumab retreatment.

Design, Setting, and Participants  Retrospective analyses were conducted of outpatients treated at an urticaria specialist center of a university hospital. Participants included 25 consecutive patients (aged 18-74 years; 18 women) with chronic spontaneous urticaria, chronic inducible urticaria, or both who showed complete response to omalizumab treatment, experienced relapse after discontinuation of treatment, and received retreatment with omalizumab.

Interventions  Subcutaneous treatment with omalizumab (150-600 mg/mo).

Main Outcomes and Measures  Response after retreatment was assessed by the urticaria activity score in patients with chronic spontaneous urticaria and by trigger threshold testing (in patients with cold urticaria or symptomatic dermographism) and/or a carefully determined history (in patients with cholinergic urticaria, solar urticaria, or pressure urticaria). Adverse events were documented.

Results  All patients experienced complete response after retreatment. None of the patients reported relevant adverse events during omalizumab treatment and retreatment.

Conclusions and Relevance  Omalizumab retreatment is effective and safe in patients with chronic urticaria who have benefited from initial omalizumab treatment.

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Figure.
Time to Urticaria Relapse After Omalizumab Treatment

Each patient is represented by a square, with colors indicating the type of urticaria disease. Two colors within a single square indicate comorbidity of 2 urticaria diseases.

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