JAMA Dermatology Clinicopathological Challenge |

A Case of Vulval Ulceration

Manuraj Singh, MD, PhD, MRCP1; Fiona Lewis, MD, FRCP2; Alistair Robson, MD, MRCPath, Dip RCPath1; Fiona Child, BsC, MD, FRCP2
[+] Author Affiliations
1Department of Dermatopathology, St John’s Institute of Dermatology, London, England
2Department of Dermatology, St John’s Institute of Dermatology, London, England
JAMA Dermatol. 2014;150(3):325-326. doi:10.1001/jamadermatol.2013.7353.
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A, Areas of vulval ulceration and swelling associated with adhesions and architectural abnormalities. B, Diagnostic biopsy showed a dense subepithelial infiltrate consisting predominantly of cells with pale vesicular nuclei and eosinophilic cytoplasm. In addition, there was a prominent accompanying eosinophilic infiltrate (hematoxylin-eosin [H&E], original magnification, ×200). C, Immunohistochemical analysis showed diffuse positivity for CD1a in most cells (original magnification, ×200).

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