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Clinical Remission of Primary Aggressive CD8+ Cutaneous T-Cell Lymphoma After Pralatrexate Infusion

Francisco A. Kerdel, MD1,2; Andrew Richard Styperek, MD, MBA1; Archana Maini, MD3
[+] Author Affiliations
1Department of Dermatology and Cutaneous Surgery, Miller School of Medicine University of Miami, Miami, Florida
2Florida Academic Dermatology Centers, Miami, Florida
3Broward Health, Broward General Medical Center, Miami, Florida
JAMA Dermatol. 2014;150(3):320-322. doi:10.1001/jamadermatol.2013.8647.
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Primary aggressive CD8+ cutaneous T-cell lymphoma (CTCL) is a rare, rapidly progressive peripheral cutaneous malignant condition. The rapid progression is accompanied by a dismal prognosis, despite attempts to treat with multiple treatment regiments. Herein, we report a case of primary aggressive CD8+ CTCL that successfully responded to pralatrexate.

Article Information

Accepted for Publication: September 14, 2013.

Corresponding Author: Francisco A. Kerdel, MD, Florida Academic Dermatology Centers, The University of Miami Hospital, 1400 NW 12th Ave, Ste 4, Miami, FL 33136 (dr.kerdel@fadcenter.com).

Published Online: January 22, 2014. doi:10.1001/jamadermatol.2013.8647.

Conflict of Interest Disclosures: Dr Kerdel received honoraria from Amgen, Abbott, and Janssen and received grants from Amgen, Abbott, Pfizer, Eli Lilly, Celgene, Stiefel, and Novartis.

Additional Contributions: We are indebted to Carlos H. Nousari, MD, Sadegh Amini, MD, and Carlos A. Vidal, MD, who were also involved in the care of this patient.

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Figure 1.
Before Treatment

An initially pruritic eruption on the upper chest progressed to multiple painful ulcerated and eroded plaques, many with yellow crust.

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Figure 2.
After Treatment

Seven months after his initial cycle of pralatrexate and aggressive supportive care, the patient’s skin showed mild erythema and hyperpigmentation. Two biopsy skin specimens were negative for malignancy.

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