0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Case Report/Case Series |

Paradoxical Adipose Hyperplasia After Cryolipolysis

H. Ray Jalian, MD1,2; Mathew M. Avram, MD, JD2,3; Lilit Garibyan, MD, PhD2,3; Martin C. Mihm, MD4; R. Rox Anderson, MD2,3
[+] Author Affiliations
1Division of Dermatology, University of California, Los Angeles, Los Angeles
2Wellman Center for Photomedicine, Massachusetts General Hospital, Boston
3Department of Dermatology, Massachusetts General Hospital, Boston
4Department of Dermatology, Brigham and Women’s Hospital, Boston, Massachusetts
JAMA Dermatol. 2014;150(3):317-319. doi:10.1001/jamadermatol.2013.8071.
Text Size: A A A
Published online

Importance  Cryolipolysis is the noninvasive reduction of fat with localized cutaneous cooling. Since initial introduction, over 650 000 cryolipolysis treatment cycles have been performed worldwide. We present a previously unreported, rare adverse effect following cryolipolysis: paradoxical adipose hyperplasia.

Observations  A man in his 40s underwent a single cycle of cryolipolysis to his abdomen. Three months following his treatment, a gradual enlargement of the treatment area was noted. This enlargement was a large, well-demarcated subcutaneous mass, slightly tender to palpation. Imaging studies revealed accumulation of adipose tissue with normal signal intensity within the treatment area.

Conclusions and Relevance  Paradoxical adipose hyperplasia is a rare, previously unreported adverse effect of cryolipolysis with an incidence of 0.0051%. No single unifying risk factor has been identified. The phenomenon seems to be more common in male patients undergoing cryolipolysis. At this time, there is no evidence of spontaneous resolution. Further studies are needed to characterize the pathogenesis and histologic findings of this rare adverse event.

Figures in this Article

Topics

hyperplasia

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Figures

Place holder to copy figure label and caption
Figure 1.
Paradoxical Adipose Hyperplasia Approximately 5 Months Following Cryolipolysis

There is a sharply demarcated, rectangular enlargement around the umbilicus corresponding to the treatment zone. This soft-tissue protrusion was soft, mobile, and slightly tender to palpation. The overlying skin was unremarkable.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.
Soft-Tissue Hyperplasia Composed of Adipose Tissue

Magnetic resonance imaging reveals increased adipose tissue with normal signal intensity. The fat hyperplasia is greatest on the periphery of the treatment zone.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 3.
Representative Biopsy Specimens From Abdominoplasty Demonstrates Characteristic Changes to Adipose Tissue

A, Histologic image from an abdominoplasty specimen of paradoxical adipose hyperplasia tissue, demonstrating thickened fibrous septae with increased vascularity (hematoxylin-eosin, original magnification ×2.50). B, Higher magnification revealed an increased vascular network, characterized by capillaries and venules (black arrowheads) (hematoxylin-eosin, original magnification ×10).

Graphic Jump Location

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Topics
PubMed Articles
Jobs
brightcove.createExperiences();