Three skin biopsy specimens were obtained. Histologic examination revealed a predominantly lobular neutrophilic panniculitis without evidence of necrosis, vasculitis, crystals, destruction of adipocytes, or infiltration at eccrine structures. Periodic acid–Schiff, Grocott, and EBER stainings were negative. Lipophagic histiocytes and giant cells were present in older lesions (Figure 2). Our differential diagnosis included pancreatic panniculitis, α1-antitrypsin deficiency, infective panniculitis, and panniculitis associated with rheumatic disease. We also considered subcutaneous Sweet syndrome, idiopathic infantile febrile panniculitis, and autoinflammatory disease.