A man in his 30s, evaluated for recently diagnosed hairy cell leukemia, developed multiple vesicles over his legs 12 hours after intravenous administration of iopamidol, a nonionic contrast media used for computed tomography (CT) scan. Three days before the onset of lesions, he had undergone his eighth session in a series of diode laser treatments for hair removal, which he tolerated well, showing no immediate injury. The patient denied taking any medication, applying any topical product, or exposing his skin to the sun. Physical examination showed multiple erythematous, vesiculous, well-defined, monomorphic plaques all over the legs and thighs. The lesions appeared only on the laser application areas, with healthy skin around (Figure).