0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Invited Commentary | Practice Gaps

Challenges in Optimizing Isotretinoin Use for Acne Vulgaris

Thomas J. McIntee, MD1; Anna L. Bruckner, MD2,3
[+] Author Affiliations
1Department of Dermatology, Marshfield Clinic, Marshfield, Wisconsin
2Department of Dermatology, Children’s Hospital Colorado, University of Colorado, Aurora
3Department of Pediatrics, Children’s Hospital Colorado, University of Colorado, Aurora
JAMA Dermatol. 2013;149(12):1398. doi:10.1001/jamadermatol.2013.7225.
Text Size: A A A
Published online

Extract

Acne vulgaris is one of the most common skin disorders affecting adolescents and young adults. Food and Drug Administration approval of isotretinoin in 1982 dramatically changed the management of nodulocystic and severe, recalcitrant acne. Isotretinoin remains the only acne treatment associated with complete remission and “cure” of nodulocystic acne. Yet despite the dramatic effect of the drug, disease relapse can occur after isotretinoin therapy.

Multiple treatment algorithms and dosing regimens have been proposed for isotretinoin, and a cumulative dose of 120 to 150 mg/kg is widely accepted as the standard treatment protocol. Alternative strategies have been designed to optimize drug dosing to achieve acceptable clinical results while minimizing adverse effects. Such regimens range from 0.2 mg/kg/d to greater than 2 mg/kg/d of isotretinoin with variations in treatment duration. These differing opinions on the dosing of isotretinoin expose a gap in our medical knowledge about optimal isotretinoin dosing for acne vulgaris.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Articles Related By Topic
Related Collections
PubMed Articles
Jobs
brightcove.createExperiences();