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Me-Too Drugs and Me-Too People

William H. Eaglstein, MD1
[+] Author Affiliations
1Department of Dermatology and Cutaneous Surgery, University of Miami, Miami, Florida
JAMA Dermatol. 2013;149(12):1375-1376. doi:10.1001/jamadermatol.2013.6759.
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Like hypotheses, concepts are important to our understanding and point the direction for actions and tests. The concept of me-too drugs is simple and powerful and misleadingly deemphasizes the value of these drugs for patients and physicians. The term me-too drug has been used in several ways, by some even to mean a generic drug.1

However, the term is historically and most accurately used to describe a drug with a mechanism of action similar to a drug already on the market. Although chemically distinct, the me-too drug will usually have a chemical structure that is similar to the first-to-market drug, which is viewed as having established the therapeutic category. These category-creating drugs are also called innovator or breakthrough drugs. Corticosteroids, retinoids, and antihistamines are examples familiar to dermatologists.

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