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Case Report/Case Series | The cutting Edge

Adalimumab for the Treatment of Refractory Acne Conglobata

Freja Lærke Sand, BSc1; Simon Francis Thomsen, MD, PhD1
[+] Author Affiliations
1Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Denmark
JAMA Dermatol. 2013;149(11):1306-1307. doi:10.1001/jamadermatol.2013.6678.
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Tumor necrosis factor (TNF) inhibitors have become important components of the treatment of multiple chronic inflammatory disorders such as psoriasis, psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis, juvenile idiopathic arthritis, Crohn disease, and ulcerative colitis. Furthermore, off-label use of TNF inhibitors has been reported for a variety of other diseases. We report a case of refractory acne conglobata treated with the TNF inhibitor adalimumab.

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Figure.
Facial Acne Conglobata Before and After Treatment With Adalimumab

A, Study patient with severe facial nodular inflammatory acne. B, Clearance 3 months after initiation of treatment with adalimumab, 40 mg, twice monthly.

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